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REGULATION OF HIPPOCAMPAL DYNORPHIN LEVELS AND SYNTHESIS AFTER ISCHEMIA

REGULATION OF HIPPOCAMPAL DYNORPHIN LEVELS AND SYNTHESIS AFTER ISCHEMIA
缺血后海马强啡肽水平和合成的调节
批准号：
3922605
负责人：
T S NOWAK
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3922605
关键词：
brain metabolism cerebral ischemia /hypoxia dynorphins gerbil /jird hippocampus histochemistry /cytochemistry messenger RNA neurochemistry neuropeptides neurotransmitter biosynthesis neurotransmitter metabolism

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英文摘要
Earlier results had demonstrated a lasting depletion of hippocampal dynorphin after ischemia in the gerbil. Immunoreactivity in hippocampal extracts remained at 50% of control levels for at least one week after a single 5 min ischemic episode. Immunocytochemical studies verify the localization of dynorphin peptides in hippocampal dentate granule cells an their mossy fiber projections to CA3. The pattern of immunoreactivity remains unchanged during recirculation after transient ischemia, suggesting that the postischemic depletion of dynorphin peptides is homogeneous throughout this cell population. Future studies will evaluate the levels and distribution of prodynorphin mRNA in hippocampus after ischemia.
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