POST-ISCHEMIC ACCUMULATION OF CALCIUM IN BRAIN TISSUE

缺血后脑组织中钙的积累

• 批准号: 3881796
• 负责人: T S NOWAK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3881796
• 关键词: autoradiography; brain cell; brain injury; brain mapping; calcium disorder; calcium metabolism; cell death; cerebral ischemia /hypoxia; cerebrovascular occlusions; corpus striatum; medial geniculate body; neurons; pyramidal cells; substantia nigra; thalamus

Observations on the distribution and the time sequences of calcium accumulation following single and repetitive ischemic insults using 45calcium autoradiography revealed significant differences in the pattern of calcium uptake between single and repeated occlusions. A striking feature of calcium accumulation in repeated ischemia was intense uptake of Ca + + in thalamus, striatum and, later, in the medial geniculate and substantia nigra. Also, a striking finding was an intense Ca + + uptake in CAl when the pyramidal neurons were virtually destroyed. Our observations suggest that abnormal accumulation of calcium may be due to other causes than a direct ischemic injury and may not necessarily indicate irreversible neuronal damage.

钙的分布和时间序列的观察