PATHOGENESIS OF CILIA-ASSOCIATED RESPIRATORY (CAR) BACILLUS INFECTIONS

纤毛相关呼吸道（CAR）芽孢杆菌感染的发病机制

• 批准号: 3937272
• 负责人: K S WAGGIE
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3937272
• 关键词: Bacillus; animal care; bacterial disease; chronic disease /disorder; communicable diseases; laboratory rat; respiratory disorder; respiratory disorder epidemiology; respiratory infections; veterinary medicine

The cilia-associated respiratory (CAR) bacillus was first demonstrated with silver stains of sections of the respiratory tract of rats by workers in the Netherlands. It was isolated in embryonated hens' eggs by the staff of the Comparative Pathology Section and is believed to be a member of the group of gliding bacteria. The Bacillus has been associated with chronic respiratory disease in rats and mice. Peribronchial lymphoid infiltrates and hyperplasia of the mucosa associated lymphoid tissue were present in rabbits naturally infected with CAR bacillus. Experimental infection via the intranasal route resulted in CAR bacillus colonization of the nasal passages but no pulmonary pathology. This suggests that CAR bacillus is a minor respiratory pathogen in rabbits.

纤毛相关呼吸道（CAR）杆菌是第一个 用呼吸道组织切片的银染证实 荷兰工人的老鼠群。 它被隔离在 比较病理学的工作人员对鸡胚进行了检查 科，并被认为是一个成员组滑翔 细菌 该杆菌与慢性 呼吸系统疾病的大鼠和小鼠。 支气管周围淋巴 粘膜相关淋巴组织浸润和增生 组织存在于自然感染CAR的兔子中 芽孢杆菌 通过鼻内途径的实验性感染导致 在鼻道的CAR杆菌定殖中， 病理 这表明CAR杆菌是一种轻微的呼吸道感染， 兔子的病原体