FIBER OPTIC PROBES

需要一个合适的装置来直接测量氧气 临床和组织中血液和组织的分压(P02) 研究应用。目前可用的测量方法 P02缺乏方便性、可靠性、速度和对许多人的适用性 感兴趣的情况。开发电子传感器的努力已经 不是很成功。希望有一个非常小的P02 可插入血管或组织的传感器 干扰小，将提供即时的P02监测 无论是短时间还是长时间。一种光纤传感器 是此应用程序的理想之选，具有以下优势 生理用途，非常小的尺寸和灵活性，安全和 低成本。一种P02传感器已经开发出来，基于 氧猝灭荧光的原理。的可行性。 对该传感器及其性能进行了验证。 在前几年的体外和体内试验中。最新进展 实现了传感器作为针状探头的功能。海流 工作已经形成了一种适合于 研究应用。

A suitable device is needed for the direct measurement of oxygen partial pressure (P02) in blood and tissue for both clinical and research applications. Methods currently available for measuring P02 lack convenience, reliability, speed, and applicability to many situations of interest. Efforts to develop electrical sensors have not been successful. It is desirable to have a very small P02 sensor that can be inserted into a blood vessel or tissue with little disturbance, which will provide instantaneous p02 monitoring for either short or extended periods of time. A fiber-optic sensor is ideal for this application, with the advantage, for physiological use, of very small size and flexibility, safety, and low cost. A P02 sensor has been developed, based upon the principle of fluorescence quenching by oxygen. The feasibility of the sensor and its satisfactory performance have been demonstrated in in vitro and in vivo tests in preceding years. The development of the sensor as a needle probe has been accomplished. The current work has resulted in the final form of an instrument suitable for research applications.