INTRATUMORAL PO2 MEASUREMENTS WITH PHOTOSENSITIZER

光纤PO2传感器仪器已经在以前 开发的将用于评估氧分压对 光动力疗法的有效性。 光动力疗法正在进行几项临床试验的评估 不同的肿瘤。细胞杀灭的主要机制被认为是 从原位分子氧生成单线态氧。这个 本研究的目的是测量肿瘤组织氧分压。 PDT，以确定是否发生严重缺氧；如果发生，是否 在光线停止后，肿瘤会重新充氧。

The fiber-optic PO2 sensor instrumentation which has been previously developed will be used to evaluate the effect of oxygen partial pressure on the effectiveness of photodynamic therapy. Photodynamic therapy is being evaluated in clinical trials for several different tumors. The primary mechanism for cell-kill is believed to be the generation of singlet oxygen from in situ molecular oxygen. The objective of this study is to measure tumor tissue oxygen tension during PDT to ascertain whether significant hypoxia occurs; and, if so, whether tumor re-oxygenation occurs after cessation of light.