FIBER OPTIC PROBES

需要一种合适的装置来直接测量氧分压 用于临床和研究的血液和组织压力（PO2） 应用.光纤传感器是这种应用的理想选择， 对于生理用途的优点是尺寸非常小，灵活，安全， 且成本低。已经开发了一种光学P02传感器，基于 氧气荧光猝灭原理。的可行性 传感器及其令人满意的性能已在体外得到证明， 前几年的体内试验。传感器的发展形式 做了一个探针，一个适合研究的仪器， 应用程序已经开发。 该系统在实验中用于测量 麻醉狗，与极谱电极测量比较 氧分压。这项工作是为了评估传感器的适用性， 糖尿病视网膜病变的研究。它导致了设计和建造 具有性能改进的仪器，适合于进一步 在这个项目和其他项目中。

A suitable device is needed for the direct measurement of oxygen partial pressure (PO2) in blood and tissue for both clinical and research applications. A fiber-optic sensor is ideal for this application, with the advantage for physiological use of very small size and flexibility, safety, and low cost. An optical P02 sensor has been developed, based upon the principle of fluorescence quenching by oxygen. The feasibility of the sensor and its satisfactory performance have been demonstrated in vitro and in vivo tests in preceding years. The development of the sensor in the form of a needle probe was done, and an instrument suitable for research applications was developed. The system was used in experiments to measure P02 in the eyes of anesthetized dogs, in comparison with polarographic electrode measurements Of PO2. This work was done to evaluate the suitability of the sensor for studies of diabetic retinopathy. It resulted in the design and construction of an instrument with performance improvements suitable for further experiments in this and other projects.