INTRATUMORAL PO2 MEASUREMENTS WITH PHOTOSENSITIZER

研制的光纤PO 2传感器仪器 先前，用于评估氧分压对 光动力疗法的有效性 光动力疗法正在进行临床试验， 不同的肿瘤 细胞杀伤的主要机制被认为是 从原位分子氧产生单线态氧。 的 本研究的目的是测量肿瘤组织的氧分压， PDT以确定是否发生显著缺氧;如果发生， 肿瘤再氧合发生在光停止之后。

The fiber-optic PO2 sensor instrumentation, which was developed previously, was used to evaluate the effect of oxygen partial pressure on the effectiveness of photodynamic therapy. Photodynamic therapy is being evaluated in clinical trials for several different tumors. The primary mechanism for cell-kill is believed to be the generation of singlet oxygen from in situ molecular oxygen. The objective of this study was to measure tumor tissue oxygen tension during PDT to ascertain whether significant hypoxia occurs; and, if so, whether tumor reoxygenation occurs after cessation of light.