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DNA Methylation and Gene Silencing in Cancer

DNA Methylation and Gene Silencing in Cancer
癌症中的 DNA 甲基化和基因沉默
批准号:
nhmrc : 293810
负责人:
Prof Susan Clark
金额:
$22.2万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-01-01 至 2006-12-31

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中文摘要
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英文摘要
In this grant we aim to study the moecular basis of cancer. The promoter regions of tumour suppressor genes are often modified in cancer by a chemical process called methylation. Methylation of DNA is associated with gene silencing. Therefore DNA methylation is commonly regarded as causing the silencing of genes in cancer. In this grant, we aim to determine if methylation is causal in triggering gene silencing in cancer, or if methylation is a consequence of gene silencing. This is a critical distinction in understanding the role of methylation in cancer development.
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Unravelling The Cancer Epigenome: Mechanisms to Translation
  • 批准号:
    nhmrc : GNT1156408
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $88.83万
  • 财政年份:
    2019
  • 负责人:
    Prof Susan Clark
  • 依托单位:
Epigenomics of Human Disease
  • 批准号:
    nhmrc : GNT1063559
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $82.29万
  • 财政年份:
    2014
  • 负责人:
    Prof Susan Clark
  • 依托单位:
Determining the causes and consequences of epigenetic remodelling in cancer and disease
  • 批准号:
    nhmrc : 1063559
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $57.57万
  • 财政年份:
    2014
  • 负责人:
    Prof Susan Clark
  • 依托单位:
Modelling epigenomic change during early breast carcinogenesis using in vitro and in vivo model systems
  • 批准号:
    nhmrc : 1029579
  • 项目类别:
    Project Grants
  • 资助金额:
    $49.57万
  • 财政年份:
    2012
  • 负责人:
    Prof Susan Clark
  • 依托单位:
海外基金