Epigenetic Silencing of Large Chromosomal Regions in Prostate Cancer.

前列腺癌大染色体区域的表观遗传沉默。

• 批准号: nhmrc : 481347
• 负责人: Prof Susan Clark
• 金额: $ 49.7万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-silencing-large-prostate-cancer/101042
• 关键词: Epigenetic; Silencing; Large; Chromosomal; Regions

Epigenetics is a term that desribes modification of gene expression without a change to the DNA sequence through processes that involve chemical change to the DNA such as methylation. In this grant we will further characterise and understand the mechanism involved in long range epigenetic silencing and determine its prevalence in prostate cancer. This study will provide potential novel targets for prostate cancer detection, prognosis and therapy.

表观遗传学是一个术语，描述了通过涉及DNA化学变化（如甲基化）的过程，在不改变DNA序列的情况下对基因表达进行修饰。在这项资助中，我们将进一步研究和了解参与长距离表观遗传沉默的机制，并确定其在前列腺癌中的流行率。本研究将为前列腺癌的检测、预后和治疗提供潜在的新靶点。