Unravelling The Cancer Epigenome: Mechanisms to Translation

揭开癌症表观基因组的神秘面纱：翻译机制

• 批准号: nhmrc : GNT1156408
• 负责人: Prof Susan Clark
• 金额: $ 88.83万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-cancer-epigenome-mechanisms-translation/1349210
• 关键词: Unravelling; Cancer; Epigenome; Mechanisms; Translation

The goal of my research is to understand how the genome is deregulated in cancer cells by delving into how DNA is organised in 3 dimensional (3D) space within the nucleus. In cancer cells, DNA can be altered epigenetically and these modifications, including chromatin structure, can cause permanent changes to gene expression. Here I will focus first on understanding how the 3D epigenome in cancer is altered and second, addressing how we can reverse these alterations using epigenetic therapies.

我研究的目标是通过深入研究DNA如何在细胞核内的三维（3D）空间中组织来了解基因组如何在癌细胞中解除管制。在癌细胞中，DNA可以表观遗传地改变，这些修饰，包括染色质结构，可以导致基因表达的永久性变化。在这里，我将首先关注癌症中的3D表观基因组是如何改变的，其次，解决我们如何使用表观遗传疗法逆转这些改变。