THE CONVERSION OF PHENYLALANINE TO TYROSINE

苯丙氨酸转化为酪氨酸

• 批准号: 3944671
• 负责人: S KAUFMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944671
• 关键词: 5 hydroxytryptophan; aminoacid metabolism; blood chemistry; chemical structure function; dihydroxyphenylalanine; enzyme induction /repression; enzyme structure; enzyme substrate; hyperphenylalaninemia; isozymes; kidney metabolism; molecular pathology; neurochemistry; neurotransmitter metabolism; nutrition related tag; phenylalanine; phenylalanine 4 monooxygenase; phenylketonurias; phosphorylation; pteridines; tyrosine; urinalysis

Phenylalanine hydroxylase activity, measured at neutral pH, can be markedly increased by a brief exposure of the enzyme to alkaline pH. Phenylalanine given to rats leads to an enhanced phosphorylation and activation of hepatic phenylalanine hydroxylase.

在中性pH下测量的苯丙氨酸羟化酶活性可 通过将酶短暂暴露于 碱性pH 给予大鼠苯丙氨酸导致磷酸化增强 和肝苯丙氨酸羟化酶的激活。