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MOLECULAR BIOLOGY OF THE PTERIN-DEPENDENT HYDROXYLASES AND ANCILLARY ENZYMES

MOLECULAR BIOLOGY OF THE PTERIN-DEPENDENT HYDROXYLASES AND ANCILLARY ENZYMES
蝶呤依赖性羟酶和辅助酶的分子生物学
批准号：
3859861
负责人：
S KAUFMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3859861
关键词：
active sites alcohol dehydrogenase aminoacid metabolism cofactor cyclic aminoacid enzyme mechanism hydrolase laboratory rat molecular cloning phenylalanine 4 monooxygenase protein structure function pteridine analog pteridines site directed mutagenesis tyrosine 3 monooxygenase

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中文摘要
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英文摘要
We are conducting an interdisciplinary investigation of the enzymes necessary for the hydroxylation of aromatic amino acids in mammals. All useful approaches to the analysis of the large variety of components involved in these and related reactions are in progress to help elucidate the basic molecular interactions in normal and diseased individuals. We have recently added tyrosine hydroxylase to the cDNAs that we have cloned and expressed to facilitate the study of mechanisms of these enzymes. We have also increased our activities in site directed mutagenesis with, for example, modifications of a number of putative functional sites in phenylalanine hydroxylase to understand the structure-function relationships in these systems.
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SYNTHESIS AND RELEASE OF BIOGENIC AMINES
BIOSYNTHESIS OF CATECHOLAMINES
PHENYLKETONURIA & OTHER DISEASES CAUSED BY DEFECTS IN BIOPTERIN-DEPENDENT ENZYMES
THE CONVERSION OF PHENYLALANINE TO TYROSINE
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