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PHENYLKETONURIA & OTHER DISEASES CAUSED BY DEFECTS IN BIOPTERIN-DEPENDENT ENZYMES

PHENYLKETONURIA & OTHER DISEASES CAUSED BY DEFECTS IN BIOPTERIN-DEPENDENT ENZYMES
苯丙酮尿症
批准号：
3859859
负责人：
S KAUFMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3859859
关键词：
aluminum brain disorders cofactor enzyme complex enzyme induction /repression enzyme mechanism glutathione peroxidase inborn aminoacid metabolism disorder liver metabolism neurochemistry oxidoreductase inhibitor phenylalanine 4 monooxygenase phenylketonurias pteridine analog

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中文摘要
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英文摘要
Glutathione peroxidase has been found to be an additional component of the hepatic phenylalanine hydroxylase system, providing protection from the deleterious effects of hydrogen peroxide. Absence of carbinolamine dehydratase activity may result in hyperphenylalaninemia and conversion of 6-biopterin to 7-biopterin. Contrary to published work, inhibition of dihydropteridine reductase by aluminum is not a factor in dialysis encephalopathy.
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SYNTHESIS AND RELEASE OF BIOGENIC AMINES
BIOSYNTHESIS OF CATECHOLAMINES
THE CONVERSION OF PHENYLALANINE TO TYROSINE
THE CONVERSION OF PHENYLALANINE TO TYROSINE
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