BRAIN MECHANISMS OF VOCAL PRODUCTION IN SQUIRREL MONKEYS

松鼠猴发声的大脑机制

• 批准号: 3942009
• 负责人: J D NEWMAN
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3942009
• 关键词: animal communication behavior; audiotape; benzodiazepines; cerebellar cortex; dosage; ethology; experimental brain lesion; limbic system; naloxone; neural information processing; neuropharmacology; pentobarbital; psychobiology; vocalization; yohimbine

This project investigates the effect of neurological and pharmacological interventions on the incidence and structure of squirrel monkey vocalizations emitted during standardized conditions in the laboratory. Current work focuses on mechanisms underlying expression of the isolation call, a characteristic vocalization used for reestablishing contact between an infant and its caregiver, and between adult social partners. Previous reports have documented the critical role of mediofrontal limbic cortex in expression of spontaneous isolation calls in squirrel monkeys, and the ability of chemicals selective for specific receptor subtypes (opiatergic mu receptor; alpha-2 adrenergic) to modulate the rate of production of this vocalization. New findings this year are: (1) subadult rhesus macaques with bilateral ablations of the amygdala continue to emit the species-typical isolatoin call, but the acoustic structure of the calls of these monkeys is abnormal, relative to age-matched controls, in exhibiting a less pronounced peak frequency in the time course of the fundamental, suggestive of reduced affective tone; (2) dose-response relations for isolation call production have been determined for the opiate antoagonist nalone over a dose range of 0.4-3.2 mg/kg, administered i.m. in adult squirrel monkeys; (3) the combined administration of naloxone and yohimbine (a specific alpha-2 adrenergic receptor antogonist) does not enhance isolation call rate, but results in a significant increase in the twitter call in separated squirrel monkeys, suggesting that under certain conditions, drugs with known anxiogenic properties may enhance behavior associated with positive affect; (4) pentobarbital sodium in sedating doses is effective in greatly enhancing production of the isolation call in adult squirrel monkeys; or (5) studies of the pharmacology of another squirrel monkey vocalization, the alarm call, suggest a role of the benzodiazepine receptor in the neurochemical control of the alarm reaction.

这个项目调查了神经和精神疾病的影响 药物干预对大鼠脑白质疏松症的发生和结构 标准化过程中发出的松鼠猴发声 实验室里的条件。目前的工作主要集中在机制上 隔离调用的基础表达式，这是一个特征 发声用于在婴儿和婴儿之间重新建立联系 它的照顾者，以及成年社交伙伴之间。以前的报告 已经证明了前额叶内侧边缘皮质的关键作用 在表达松鼠猴子自发的隔离叫声时， 以及化学物质对特定受体的选择能力 亚型(阿片能Mu受体；α-2肾上腺素能)调节 发声的速度这种发声的速度今年的新发现 有：(1)亚成体恒河猴双侧大脑中动脉消融 杏仁核继续发出物种典型的孤立叫声，但 这些猴子叫声的声学结构是异常的， 相对于年龄匹配的对照组，在表现出不那么明显的 峰值频率在时间进程中的基本，提示性 情感语调降低；(2)隔离的剂量-反应关系 已确定阿片类抗激动剂的CALL产量 在0.4-3.2 mg/kg的剂量范围内，单独肌肉注射。在……里面 成年松鼠猴；(3)联合给药 纳洛酮和育亨宾(一种特异性的α2肾上腺素能受体) 自鸣者)不会提高隔离呼叫率，但会导致 分离松鼠的推特通话显著增加 猴子，这表明在某些情况下，药物与 已知的导致焦虑的特性可能会增强相关行为 (4)戊巴比妥钠镇静剂量为 有效地极大地提高了隔离呼叫的产量 成年松鼠猴；或(5)丹参药理研究 另一种松鼠猴子的叫声，警报声，暗示着 苯二氮卓类受体在神经化学调控中的作用 惊慌的反应。