ANTIDEPARESSANT EFFECTS OF LIGHT IN SEASONAL AFFECTIVE DISORDER AND NORMAL CONTRO

光对季节性情感障碍和正常控制的抗抑郁作用

• 批准号: 3944723
• 负责人: N E ROSENTHAL
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944723
• 关键词: antidepressants; bioperiodicity; chronotherapy; circadian rhythms; depression; human subject; light intensity; lighting; photobiology; phototherapy; psychobiology; psychosomatic disorders; seasons; sleep deprivation; visible light; visual photoreceptor

We have previously shown that exposure of the eyes to bright light, but not ordinary room light, can reverse the winter depressive symptoms in patients with seasonal affective disorder (SAD). This light treatment may be effective during the morning, the evening or even during ordinary daylight hours. Normal subjects with no history of winter difficulties do not seem to benefit from this light treatment. This past year we have gone on to study whether light in a narrow band of the visual spectrum (blue or red) is as effective as the full-spectrum light used previously. We have also asked whether normal subjects who complain of mild winter difficulties might benefit from conventional bright light treatment. In a crossover study on 21 subjects we found that although full- spectrum light tended to be more effective than either blue or red light, this did not reach statistical significance, perhaps because the narrow-band light was clinically active to some degree. If this is so, it would suggest that the antidepressant effects of light in SAD are mediated by wavelengths that span the full visual spectrum. A separate study of full-spectrum light in 40 normal subjects, 20 with and 20 without a history of mild winter difficulties, such as low energy level or decreased productivity, showed that the former group benefited from light treatment whereas the latter group did not. The degree of improvement was related to the duration of treatment, 5 hours per day proving superior to 2 hours per day. Since there seems to be a high prevalence of normal subjects with mild winter difficulties, this finding may have widespread public health implications.

我们以前已经证明，眼睛暴露在明亮的光线中， 光线，但不是普通的房间光，可以扭转冬天 季节性情感障碍患者的抑郁症状 （SAD）。 这种光治疗在早上可能有效， 在晚上，甚至在普通的白天。 正常 没有冬季困难史的受试者似乎 从这种光治疗中受益。 在过去的一年里， 研究可见光谱中的窄波段光 (blue或红色）与使用的全光谱光一样有效 以前。 我们还询问了正常受试者， 抱怨温和的冬季困难可能会受益于 传统的强光治疗。 在一项针对21名受试者的交叉研究中，我们发现，尽管完全- 光谱光往往比蓝色或红色更有效 光，这并没有达到统计学意义，也许是因为 窄带光在一定程度上具有临床活性。 如果 这就意味着光的抗抑郁作用 在SAD中是由跨越整个视觉的波长介导的 江西篇章 40例正常人全光谱光的单独研究 受试者，20例有和20例无暖冬史 困难，如能量水平低或生产力下降， 表明前一组受益于光照处理， 而后一组则没有。 改善程度为 与治疗持续时间相关，每天5小时，证明 上级至每天2小时。 因为似乎有一个高 患病率正常受试者有轻微的冬季困难，这 这一发现可能会对公众健康产生广泛影响。