ANTIDEPRESSANT EFFECTS OF LIGHT IN SEASONAL AFFECTIVE DISORDER

光疗对冬季季节性疾病疗效的研究进展 情感障碍(SAD)使用了灯箱，尽管 有效和安全，是繁琐的，有时也不方便。一个 头戴式便携式光传输系统已经发明， 由NIMH和At的内部计划的研究人员开发 杰斐逊医学院试图找到一种更方便的灯光 治疗来源。去年冬天，我们参加了第三届 多年来对该设备进行了多中心临床试验。最新的 这项研究没有作为CRADA的一部分与Bio-Brite，Inc.进行 贝塞斯达，马里兰州，遮阳板的制造商，尽管该公司 免费提供护目镜。 在之前的两项研究中，我们发现不同的护目镜 强度变化很大(从60勒克斯到5000勒克斯)。尽管所有人 治疗似乎相当有效，但问题仍然是 这种效应是完全由安慰剂效应引起的，还是由特定的 效果也是如此。为了解决这个问题，我们进行了第三项研究， 其中有一个非常暗的(30勒克斯)红色遮阳板，我们预测它会起作用 只是作为一种安慰剂，被比作更亮(600勒克斯)的白色 来自两个中心的57名SAD患者的Visor平行设计(NIMH， 医学博士贝塞斯达和马萨诸塞州贝尔蒙特麦克莱恩医院)被随机分配到 使用30勒克斯的红色遮阳板或600勒克斯的白色遮阳板进行治疗。 治疗持续2周，每天早晨给药30分钟。 两个面罩的总体响应率，使用严格响应 标准，约为40%。因此，我们的预测是较暗的 面罩将比未确认的亮色面罩更有效。 对这一发现的可能解释进行了讨论。

Previous studies of the efficacy of light therapy for winter seasonal affective disorder (SAD) have utilized light boxes, which, though effective and safe, are cumbersome and, at times, inconvenient. A head-mounted, portable light delivery system has been invented and developed by researchers in the Intramural Program of the NIMH and at Jefferson Medical College in an attempt to find a more convenient light treatment source. This past winter, we participated in the third multicenter clinical trial of this device in as many years. The latest study was not performed as part of a CRADA with Bio-Brite, Inc. of Bethesda, MD, the manufacturer of the visor, though the company did provide the visors without charge. In the two earlier studies, we found no difference between visors of widely varying intensities (from 60 to 5000 lux). Although all treatments appeared to be fairly effective, the question remained as to whether this effect was due solely to the placebo effect or to specific effects as well. To address this question, we undertook a third study, in which a very dim (30 lux) red visor, which we predicted would function only as a placebo, was compared to a somewhat brighter (600 lux) white visor in a parallel design in 57 patients with SAD from 2 centers (NIMH, Bethesda, MD and McLean Hospital, Belmont, MA) were assigned randomly to treatments with either a 30-lux red visor or a 600-lux white visor. Treatments were administered for 30 minutes each morning for 2 weeks. The overall response rate for both visors, using stringent response criteria, was approximately 40%. Thus, our prediction that the dimmer visor would be more effective than the brighter one was not confirmed. Possible explanations for this finding are discussed.