EPIDEMIOLOGIC STUDIES OF DIET AND CANCER HAWAII

该项目以饮食流行病学研究为主题。 和夏威夷多民族人口中的癌症。它汇集了两个 我们当前研究的几个方面：关于饮食在癌症中作用的研究 病因学和流行病学研究中的饮食方法论研究。 七个独立但相互关联的项目，并提出了。其中四个是 癌症的病因学研究(包括结肠癌、乳腺癌、甲状腺、肺癌、 膀胱和其他)与饮食暴露于特定食物和 它们的营养成分(如脂肪、胆固醇和维生素)。这些 四项研究同时涉及队列和病例对照方法，并在此基础上 我们早期的横断面和病例对照研究的结果。数据 收集主要涉及个人面谈和监视， 尽管生物标本也将在其中一个 学习。另外三项研究考察了节食史的不同方面 方法，包括其有效性、重复性和等效性 量化膳食摄入量的不同方法。所有七个项目 需要相当多的专业和技术人员重叠，因为 在使用核心支持组件方面也是如此。这项研究计划 不仅应该提高我们对饮食因素在 癌症的病因，但也导致更好的饮食历史数据 收集方法，为今后的流行病学研究。

This Program Project Grant has as its theme epidemiologic research on diet and cancer in the multiethnic population of Hawaii. It brings together two aspects of our current research: studies on the role of diet in cancer etiology, and studies of dietary methodology in epidemiologic research. Seven separate but interrelated projects and proposed. Four of these are etiologic studies of cancer (including colon, breast, thyroid, lung, bladder and others) in relation to dietary exposures to specific foods and their nutrient components (such as fats, cholesterol and vitamins). These four studies involve both cohort and case-control approaches, and build on the results of our earlier cross-sectional and case-control studies. Data collection primarily involves personal interviews and surveillance, although biological specimens will also be collected in one of the studies. Three other studies examine different aspects of the diet history method, including its validity, its reproducibility, and the equivalence of different methods for quantifying dietary intakes. All seven projects entail considerable overlap in professional and technical personnel, as well as in the use of core support components. This research program should not only advance our knowledge about the role of dietary factors in the etiology of cancer, but also lead to better dietary history data collection methods for future epidemiological studies.