EPIDEMIOLOGIC STUDIES OF DIET AND CANCER IN HAWAII

这是一份计划项目补助金或 饮食和癌症流行病学的主题。 这一主题是追求与 探索病因学假设以及方法学的研究 饮食评估方面。 在目前的支助期间， 一个基于人群的42,000名受试者的前瞻性队列正在 癌症发病率与先前饮食的关系 病例对照研究正在检验饮食假设 与肺癌、膀胱癌和甲状腺癌有关; 饮食史方法正在评估召回的准确性，因为 以及病例与对照组之间的回忆差异， 代理受访者与直接受访者之间的差异。 所有这些项目都取得了重大进展， 提出了初步调查结果。 在更新期间，6 建议的项目有：1）继续监测癌症 前瞻性队列的发病率; 2）病例对照研究（1057 例，1057名对照）的膳食脂肪，纤维和 钙摄入量以及能量平衡与结直肠癌的关系 风险; 3）病例对照研究（391例，782例对照）， 膳食脂肪和维生素A与子宫内膜异位症的可能关联 癌症风险; 4）饮食因素与癌症的相关性研究 菲律宾人、高加索人和日本移民到夏威夷的发病率; 5)膳食营养不良的病例对照研究（231例，462例对照） 维生素A、C、E和硒与皮肤病风险的关系 高加索人中的恶性黑色素瘤; 6）电话的发展 定量饮食史评估访谈法。 的 病例对照研究将涉及受试者的直接访谈， 他们的家园，使用定量饮食史方法与视觉 艾滋病 此外，恶性黑色素瘤的研究将包括 用于测定视黄醇、胡萝卜素、α- 生育酚和硒。 对前瞻性队列的随访将 需要与夏威夷肿瘤登记处的计算机记录连接 以及其他重要记录 电话采访研究将 包括与300人进行面对面和电话访谈 科目 数据收集、处理和分析 项目是高度一体化的，并提供了协同作用， 经济的努力，否则是不可能的。 的 这些研究的结果应该进一步加深我们对 饮食与癌症风险的关系，并加强基础 今后在初级预防方面的公共卫生工作 癌

This is a renewal application for a Program Project Grant or the theme of diet and cancer epidemiology. This theme is pursued with studies that explore etiologic hypotheses as well as methodologic aspects of dietary assessment. In the current period of support, a population-based prospective cohort of 42,000 subjects is being followed for cancer incidence in relation to antecedent dietary intakes; case-control studies are testing dietary hypotheses related to lung, bladder and thyroid cancers; and the quantitative diet history method is being evaluated for accuracy of recall, as well as for differences in recall between cases versus controls and between proxy respondents versus directly-interviewed subjects. Substantial progress is being made on all of these projects and preliminary findings are presented. In the renewal period, six projects are proposed: 1) continued surveillance for cancer incidence in the prospective cohort; 2) a case-control study (1057 cases, 1057 controls) of the relationship of dietary fat, fiber and calcium intake, as well as energy balance, to colorectal cancer risk; 3) a case-control study (391 cases, 782 controls) of the possible association of dietary fat and vitamin A with endometrial cancer risk; 4) a correlational study of dietary factors and cancer incidence in Filipino, Caucasian and Japanese migrants to Hawaii; 5) a case-control study (231 cases, 462 controls) of dietary vitamins A, C and E and selenium in relation to risk of cutaneous malignant melanoma among Caucasians; 6) development of a telephone interview method for quantitative diet history assessment. The case-control studies will involve direct interviews of subjects in their homes, using a quantitative diet history method with visual aids. In addition, the study of malignant melanoma will include serum collections for assays of retinol, carotenes, alpha- tocopherol and selenium. Follow-up on the prospective cohort will entail computerized record-linkage with the Hawaii Tumor Registry and other vital records. The telephone interview study will include both face-to-face and telephone interviews with 300 subjects. Data collection, processing and analysis for these projects is highly integrated, and provides for synergism and economy in effort that would not otherwise be possible. The results of these studies should further our knowledge of the relationship of diet to cancer risk and strengthen the foundation for future public health efforts in the primary prevention of cancer.