MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER

饮食与癌症的多民族/少数民族队列研究

• 批准号: 2095793
• 负责人: LAURENCE N. KOLONEL
• 金额: $ 232.46万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-02-15 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2095793
• 关键词: African American; Hispanic Americans; Japanese American; breast neoplasms; caloric dietary content; cancer registry /resource; cancer risk; caucasian American; colorectal neoplasms; data collection methodology /evaluation; dietary constituent; dietary fiber; dietary lipid; ethnic group; human data; human middle age (35-64); human old age (65+); lifestyle; lung neoplasms; nutrient intake activity; nutrition related neoplasm /cancer; nutrition related tag; prostate neoplasms; questionnaires; racial /ethnic difference

This project will investigate dietary and other lifestyle risk factors for cancer. Specifically, it will: 1) establish a large, multiethnic cohort (including several minority groups much in need of study) which will allow us to test a variety of hypotheses related to dietary and other risk factors; and 2) follow the cohort for incidence of cancer, as well as other chronic diseases. A substantial amount of work has already been accomplished towards these goals. A self-administered questionnaire, with a major dietary component, has been developed and pre-tested. In addition, a pilot study that entailed mailouts to 6,000 randomly selected individuals (representing the 4 ethnic groups included in this proposal) yielded an overall response rate of 52.3%, demonstrating the feasibility of the project. The study will consist of questionnaire mailings over a 2-year period to men and women aged 45-79, randomly selected from the four ethnic groups (blacks, Hispanics, Japanese, and Nonhispanic whites), in order to obtain a total cohort of 327,020 sons. In addition to a Quantitative diet history, the questionnaire will include background information as well as medical, medication, physical activity, and female reproductive histories. Drivers' license files will provide the sampling frame, and, based on the results of the pilot, will yield a participant group with notable differences in the food sources of particular nutrients among ethnic groups and a wide range of nutrient intakes within each group. Surveillance will begin in the third year, utilizing computer linkages with the population-based Hawaii and California statewide tumor registries, and direct contact with the subjects. After 4-5 years of follow-up on the cohort, the number of incident cases for several cancer sites will be adequate to address in the data analysis the major dietary hypotheses. Strengths of this project include its prospective design, large size, ethnic diversity, minority component, selection of subjects from the general population, variation in food sources and range of intake of nutrients, and the developmental work already completed. The findings should contribute significantly to the future primary prevention of cancer.

该项目将调查饮食和其他生活方式的风险因素 对于癌症。 具体来说，它将：1）建立一个大型的、多民族的 队列（包括几个急需研究的少数群体） 将使我们能够测试与饮食和饮食相关的各种假设 其他风险因素； 2) 跟踪癌症发病率队列，如 以及其他慢性疾病。 大量工作已经完成 已实现这些目标。 一个自我管理的 已经制定了包含主要饮食成分的调查问卷 预先测试。 此外，还进行了一项试点研究，向 6,000 人发送邮件 随机选择的个体（代表 4 个民族，包括 在本提案中）的总体响应率为 52.3%， 论证该项目的可行性。 该研究将包括为期 2 年的调查问卷邮寄 45-79岁的男性和女性，从四个民族中随机抽取 （黑人、西班牙裔、日本人和非西班牙裔白人），以获得 共有 327,020 名儿子。 除了定量饮食 历史，调查问卷将包括背景信息以及 医疗、药物、体力活动和女性生殖 历史。 驾驶执照文件将提供样本框架，并且， 根据试点结果，将产生一个参与者组 特定营养素的食物来源存在显着差异 种族群体以及每个群体内的各种营养素摄入量。 监控将于第三年开始，利用计算机连接 夏威夷和加利福尼亚州以人口为基础的肿瘤 登记处以及与受试者的直接联系。 经过4-5年 对队列进行随访，几种癌症的发病病例数 网站将足以在数据分析中解决主要饮食问题 假设。 该项目的优势包括设计前瞻性、规模大、 种族多样性、少数民族成分、从 一般人群、食物来源和摄入量范围的变化 营养物质，并且发育工作已经完成。 研究结果 应该对未来的一级预防做出重大贡献 癌症。