MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER

这个项目将调查饮食和其他生活方式的危险因素 治疗癌症 具体而言，它将：1）建立一个大的，多民族的， 队列（包括几个非常需要研究的少数群体）， 将使我们能够测试各种与饮食有关的假设， 其他风险因素;以及2）跟踪癌症发病率的队列，如 以及其他慢性疾病。 大量的工作已经 实现这些目标。 自填式 已经编制了一份调查表，其中包括主要的饮食内容， 预先测试。 此外，一项试点研究，需要邮寄到6000 随机选择的个体（代表包括的4个种族群体 在本建议中）的总体答复率为52.3%， 论证项目的可行性。 这项研究将包括在2年内邮寄调查问卷， 年龄介乎45至79岁的男女，从四个种族组别中随机选出 （黑人，西班牙裔，日本人和非西班牙裔白人），以获得 总共有327,020个儿子。 除了定量饮食 调查表将包括背景资料以及 医疗、药物、体育活动和女性生殖 历史 驾驶执照文件将提供抽样框架， 根据试点的结果，将产生一个参与者组， 在特定营养素的食物来源之间的显着差异 种族群体和每个群体内广泛的营养摄入量。 监测将在第三年开始，利用计算机连接 以人口为基础的夏威夷和加州全州肿瘤 登记处，以及与受试者的直接联系。 经过4-5年的 对队列的随访，几种癌症的发病病例数 研究中心将足以在数据分析中解决主要的饮食问题， 假设 该项目的优势包括其前瞻性的设计，大规模， 种族多样性，少数民族成分， 一般人口、食物来源的变化和 营养素和开发工作已经完成。 这些发现 应大大有助于今后的初级预防， 癌

This project will investigate dietary and other lifestyle risk factors for cancer. Specifically, it will: 1) establish a large, multiethnic cohort (including several minority groups much in need of study) which will allow us to test a variety of hypotheses related to dietary and other risk factors; and 2) follow the cohort for incidence of cancer, as well as other chronic diseases. A substantial amount of work has already been accomplished towards these goals. A self-administered questionnaire, with a major dietary component, has been developed and pre-tested. In addition, a pilot study that entailed mailouts to 6,000 randomly selected individuals (representing the 4 ethnic groups included in this proposal) yielded an overall response rate of 52.3%, demonstrating the feasibility of the project. The study will consist of questionnaire mailings over a 2-year period to men and women aged 45-79, randomly selected from the four ethnic groups (blacks, Hispanics, Japanese, and Nonhispanic whites), in order to obtain a total cohort of 327,020 sons. In addition to a Quantitative diet history, the questionnaire will include background information as well as medical, medication, physical activity, and female reproductive histories. Drivers' license files will provide the sampling frame, and, based on the results of the pilot, will yield a participant group with notable differences in the food sources of particular nutrients among ethnic groups and a wide range of nutrient intakes within each group. Surveillance will begin in the third year, utilizing computer linkages with the population-based Hawaii and California statewide tumor registries, and direct contact with the subjects. After 4-5 years of follow-up on the cohort, the number of incident cases for several cancer sites will be adequate to address in the data analysis the major dietary hypotheses. Strengths of this project include its prospective design, large size, ethnic diversity, minority component, selection of subjects from the general population, variation in food sources and range of intake of nutrients, and the developmental work already completed. The findings should contribute significantly to the future primary prevention of cancer.