Multiethnic Cohort Study of Diet and Cancer

饮食与癌症的多种族队列研究

• 批准号: 7926117
• 负责人: LAURENCE N. KOLONEL
• 金额: $ 28.73万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926117
• 关键词: African American; Breast; Caucasians; Caucasoid Race; Cohort Studies; Data; Data Analyses; Databases; Diet; Environmental Risk Factor; Ethnic group; Food; Genes; Genetic Predisposition to Disease; Hawaiian population; Heme Iron; Heterocyclic Amines; Histology; Hormonal; Institution; Investigation; Japanese American; Kidney; Knowledge; Latino; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Non-Hodgkin' s Lymphoma; Ovary; Paper; Participant; Pharmaceutical Preparations; Physical activity; Postdoctoral Fellow; Publishing; Questionnaires; Research; Research Personnel; Risk Factors; Role; Site; Smoking; Staging; Subgroup; Susceptibility Gene; Training; Trans Fatty Acids; Update; Work; base; cancer risk; cohort; design; diet and cancer; dietary constituent; ethnic difference; follow-up; gene environment interaction; graduate student; lifestyle factors; member; racial and ethnic disparities

¿' . ' ' ' . The Multiethnic Cohort (MEC) Study was designed to prospectively investigate the relationship of diet and other lifestyle factors to cancer risk in five ethnic groups (African Americans, Japanese Americans, Latinos, Native Hawaiians and Caucasians),and to explore interactions between these risk factors and genetic susceptibility to cancer. Since establishment of the cohort in 1993-96, more than 10 years of follow-up have accrued on the 215,000 participants, bringing the project to a point where its full potential can now be realized. In the current cycle of support, we are re-administering the baseline questionnaire to obtain updated (10-year) dietary and other information on the subjects (e.g., smoking, physical activity, hormonal usage, medications, intercurrent illnesses). We have been analyzing data from the baseline questionnaire, both dietary and non-dietary, as well as data on genetic susceptibility and gene-environment interactions. Altogether, we have published 50 papers from the cohort since early 2003. We have been among the most active participants in NCI's Breast and Prostate Cancer Cohort Consortium, and have shared our data with other members of the consortium, as well as with investigators at outside institutions. For the next 5-year period, we have several dietary scientific aims, including further research into the basis for ethnic differences we observed in diet and cancer relationships, investigation of hypotheses related to dietary constituents recently added to our food composition table (e.g., trans fatty acids, heme iron, glycemic load, heterocyclic amines), study of some less common sites (e.g., non-Hodgkin's lymphoma, ovary and kidney), more in-depth subgroup analyses (e.g., by histology and stage), and investigations of the relationship of diet to cancer survival. We also have several non-dietary scientific aims, particularly related to investigating as- yet unexplainable ethnic differences in breast and lung cancer risk. The important work necessary to maintain the cohort and its several databases will continue, including administration of another short follow- up questionnaire and regular enhancements to the unique food composition table. Finally, we will continue to train graduate students and postdoctoral fellows. We expect this research not only to expand knowledge of the role of environmental risk factors and genes in cancer risk, but also to further an understanding of the basis for ethnic/racial disparities in cancer occurrence and survival.

是的。' ' ' . 多种族队列研究（MEC）旨在前瞻性地调查饮食和 其他生活方式因素对五个种族（非裔美国人，日裔美国人，拉丁美洲人， 夏威夷原住民和高加索人），并探讨这些风险因素和遗传因素之间的相互作用， 对癌症的易感性。自1993-96年建立队列以来，10多年的随访表明， 215，000名参与者，使该项目达到了现在可以充分发挥其潜力的程度 实现了在目前的支助周期中，我们正在重新进行基线问卷调查， 关于受试者的更新的（10年）饮食和其他信息（例如，吸烟，体力活动，荷尔蒙 用法、药物、并发疾病）。我们一直在分析基线问卷的数据， 饮食和非饮食，以及遗传易感性和基因-环境相互作用的数据。 自2003年初以来，我们共发表了50篇论文。我们是世界上 NCI乳腺癌和前列腺癌队列联盟的积极参与者，并与 合作体的其他成员以及外部机构的调查人员。未来五年 在此期间，我们有几个饮食科学的目标，包括进一步研究民族的基础， 我们观察到的饮食和癌症关系的差异，与饮食相关的假设的调查， 最近添加到我们的食物组成表中的成分（例如，反式脂肪酸，血红素铁，血糖负荷， 杂环胺），一些不太常见的位点的研究（例如，非霍奇金淋巴瘤、卵巢和肾）， 更深入的亚组分析（例如，通过组织学和阶段），并调查饮食的关系， to cancer癌症survival生存.我们也有几个非饮食科学的目标，特别是有关调查，因为- 但却无法解释的乳腺癌和肺癌风险的种族差异。必要的重要工作 维持队列和它的几个数据库将继续，包括另一个简短的后续管理- 调查问卷和定期改进独特的食物成分表。最后，我们将继续 培养研究生和博士后。我们希望这项研究不仅能扩大知识 环境风险因素和基因在癌症风险中的作用，同时也进一步了解 癌症发生率和生存率的种族/种族差异的基础。