DISPOSITION OF HALOGENATED DIBENZOFURANS

卤代二苯并呋喃的处置

• 批准号: 3965175
• 负责人: L S BIRNBAUM
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965175
• 关键词: chemical structure function; dioxins; embryo /fetus toxicology; environmental toxicology; gastrointestinal toxin absorption; genetic strain; halobiphenyl /halotriphenyl compound; halogenation; isomer; polychlorodibenzofuran; toxicant screening; toxin metabolism

Halogenated dibenzofurans are found worldwide as environmental pollutants. Structurally related to other halogenated aromatic xenobiotics, their toxicity and disposition seem to vary with the degree and position of halogenation. This work has established that 2,3,7,8,-tetrachlorodibenzofuran (TCDF), an extremely toxic isomer, is excreted only after metabolism and toxicity is inversely related to metabolic capability. The distribution to the fetus was examined after maternal exposure. The role of body composition on the disposition of 2,3,7,8-tetrachlorodibenzodioxin (TCDD), the most toxic man-made compound known, has been examined in congenic mouse strains which are sensitive or resistant to TCDD toxicity and shown to be a major determinant of disposition. The disposition of octachlorodibenzodioxin (OCDD) was also studied in rats. Studies with 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) have begun in rats and monkeys.

卤代二苯并呋喃是世界范围内发现的环境污染物。 结构上与其他卤代芳香族异生物质相关， 毒性和处置似乎随着程度和位置的变化， 卤化反应 这项工作已经确定， 2，3，7，8-四氯二苯并呋喃（TCDF）是一种剧毒异构体， 仅在代谢和毒性后排泄， 代谢能力 检查了胎儿的分布， 母体暴露 身体成分对处置的作用 2，3，7，8-四氯二苯并二恶英（TCDD），毒性最大的人造化合物 已知，已在敏感或 抗TCDD毒性，并显示是一个主要的决定因素， 处分 八氯二苯并二恶英（OCDD）的处置也 在老鼠身上研究。 2，3，4，7，8-五氯二苯并呋喃（4-PeCDF）研究 已经开始在老鼠和猴子身上。