LYMPHOCYTES AND LMYPHOKINES IN APLASTIC ANEMIA

我们实验室之前的研究表明， 激活的抑制性淋巴细胞产生抑制性淋巴因子，如 致病于骨髓衰竭患者。这些细胞是 可在患者循环中检测到异常高的数量 再生障碍性贫血。激活抑制子产生干扰素的研究 细胞可能解释了其他实验室之前的结果显示 正常造血患者细胞共培养中的抑制作用。 目前的研究主要针对淋巴细胞表型的变化。 和淋巴因子的产生 抗胸腺细胞球蛋白(ATG)；ATG在再生障碍性疾病中的作用机制 贫血；以及γ干扰素与其他可溶物质的体外相互作用 免疫功能的中介物。再生障碍性贫血的研究范围有 通过与远东调查人员的合作扩大了范围，在那里 再生障碍性贫血是一种比美国或 西欧。

Previous studies from our laboratory have implicated a population of activated suppressor lymphocytes which produce an inhibitory lymphokine as pathogenic in patients with bone marrow failure. These cells are detectable in abnormally high numbers in the circulation of patients with aplastic anemia. Production of gamma interferon by activated suppressor cells probably explains other laboratories' previous results showing inhibition in co-culture by patients' cells of normal hematopoiesis. Current studies have been directed at the changes in lymphocyte phenotypes and lymphokine production in patients that follow treatment with antithymocyte globulin (ATG); the mechanism of action of ATG in aplastic anemia; and the interaction in vitro of gamma interferon with other soluble mediators of immune function. The scope of studies of aplastic anemia has been broadened by collaborations with investigators in the Far East, where aplastic anemia is a more common disorder than in the United States or Western Europe.