Characterisation of atrial arrhythmia substrate - development of a novel predictive tool to guide catheter ablation of atrial fibrillatio

房性心律失常基质的表征 - 开发一种新型预测工具来指导房颤导管消融

• 批准号: G1000326/1
• 负责人: Nick Linton
• 金额: $ 28.23万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000326%2F1
• 关键词: Characterisation; atrial; arrhythmia; substrate; development

Atrial fibrillation (AF) is the most common cardiac arrhythmia, during which the top chambers of the heart (atria) have chaotic electrical activation. This has many effects, including palpitation and an increased risk of stroke. In the early stages, AF usually ‘starts and stops‘ but with time the periods of AF become longer. Eventually, many patients have AF that is persistent. Catheter ablation can cure around 90% of patients with the intermittent AF but the persistent form of AF is not so well understood and catheter ablation is less successful.Patients will be studied who are having electrodes placed (temporarily) in their heart as part of their routine treatment. We will stimulate the atria from multiple sites and record the electrical activation, building 3D electrical maps of conduction at different heart rates. The electrical maps will be compared with scar measurements made with MRI scans.Comparisons of atrial conduction will be made between patients a) without AF, b) with intermittent AF, and c) with persistent AF. This will provide information about the particular sites within the atria that are abnormal in patients with AF. Hopefully this improved understanding will lead to greater effectiveness and safety of ablation for persistent atrial fibrillation.

心房颤动 (AF) 是最常见的心律失常，在此期间心脏的顶部心室（心房）出现混乱的电激活。这会产生很多影响，包括心悸和中风风险增加。在早期阶段，房颤通常会“开始和停止”，但随着时间的推移，房颤的周期会变得更长。最终，许多患者患有持续性房颤。导管消融可以治愈大约 90% 的间歇性 AF 患者，但对持续性 AF 的了解还不太清楚，导管消融不太成功。将对在心脏中（临时）放置电极作为常规治疗一部分的患者进行研究。我们将从多个部位刺激心房并记录电激活，构建不同心率下传导的 3D 电图。电图将与 MRI 扫描进行的疤痕测量进行比较。将在 a) 无 AF 患者、b) 间歇性 AF 患者和 c) 持续性 AF 患者之间进行心房传导比较。这将提供有关 AF 患者心房内异常特定部位的信息。希望这种加深的理解能够提高持续性心房颤动消融的有效性和安全性。