The neural basis of perceptual sensitivity to sound in auditory cortex of the mouse.

小鼠听觉皮层对声音感知敏感性的神经基础。

• 批准号: G1000512/1
• 负责人: Paul Chadderton
• 金额: $ 154.34万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000512%2F1
• 关键词: neural; basis; perceptual; sensitivity; sound

The auditory world is noisy and full of distractions, but our brains are remarkably good at detecting, and extracting important sounds while ignoring the background. If a person mentions your name at the other end of a noisy room, it is quite likely that you will stop what you‘re doing, and listen to the speaker‘s words. As you do this, you lose awareness of the other noisy goings on around you. How the brain performs this amazing task is the subject of my research. My goals are to determine: - How the brain responds to important sounds when they occur in noisy environments.- How the brain improves sound detection in noisy environments using the natural properties of sound.- How the brain signals that it has heard an important sound.To do this, I‘m going to present sounds to mice and record brain activity in auditory cortex, which is thought to be involved in higher-level processing of sound. I will train mice to perform a task where they must listen and indicate when they have heard a particular sound. I will explore whether their brain activity differs between occasions when indicate they have or have not heard the sound.

听觉世界是嘈杂的，充满了干扰，但我们的大脑非常善于检测和提取重要的声音，而忽略了背景。如果一个人在一个嘈杂的房间的另一端提到你的名字，你很可能会停止你正在做的事情，听说话者的话。当你这样做的时候，你会失去对周围其他嘈杂事物的意识。大脑如何执行这一惊人的任务是我研究的主题。我的目标是确定：-大脑如何响应重要的声音时，他们发生在嘈杂的环境。大脑如何利用声音的自然特性在嘈杂的环境中提高声音检测。大脑是如何发出听到重要声音的信号的。为了做到这一点，我将向老鼠展示声音，并记录大脑听觉皮层的活动，听觉皮层被认为与声音的高级处理有关。我将训练老鼠执行一项任务，它们必须倾听并在听到特定声音时做出指示。我将探索他们的大脑活动是否在表明他们听到或没有听到声音的情况下有所不同。