The neural basis of perceptual sensitivity to sound in auditory cortex of the mouse.

听觉世界是嘈杂的，充满了干扰，但我们的大脑非常擅长探测和提取重要的声音，而忽略背景。如果一个人在一个嘈杂的房间的另一端提到你的名字，你很可能会停下手头的工作，倾听说话人的话。当你这样做的时候，你失去了对周围其他嘈杂声的意识。我的研究主题是大脑如何完成这项惊人的任务。我的目标是确定：-大脑在嘈杂环境中对重要声音的反应。-大脑如何利用声音的自然属性在嘈杂的环境中提高声音探测能力。——大脑是如何发出听到重要声音的信号的。为了做到这一点，我将给老鼠播放一些声音，并记录下听觉皮层的大脑活动，听觉皮层被认为与声音的高级处理有关。我将训练老鼠完成一项任务，在这项任务中，它们必须倾听，并在听到特定声音时指出来。我将探索他们的大脑活动是否在不同的场合有所不同，表明他们听到或没有听到声音。

The auditory world is noisy and full of distractions, but our brains are remarkably good at detecting, and extracting important sounds while ignoring the background. If a person mentions your name at the other end of a noisy room, it is quite likely that you will stop what you‘re doing, and listen to the speaker‘s words. As you do this, you lose awareness of the other noisy goings on around you. How the brain performs this amazing task is the subject of my research. My goals are to determine: - How the brain responds to important sounds when they occur in noisy environments.- How the brain improves sound detection in noisy environments using the natural properties of sound.- How the brain signals that it has heard an important sound.To do this, I‘m going to present sounds to mice and record brain activity in auditory cortex, which is thought to be involved in higher-level processing of sound. I will train mice to perform a task where they must listen and indicate when they have heard a particular sound. I will explore whether their brain activity differs between occasions when indicate they have or have not heard the sound.