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CLINICAL AND THERAPEUTIC STUDIES IN HUMAN FILARIASIS

CLINICAL AND THERAPEUTIC STUDIES IN HUMAN FILARIASIS
人类丝虫病的临床和治疗研究
批准号：
4688548
负责人：
E A OTTESEN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4688548
关键词：
drug screening /evaluation filariasis parasitic disease chemotherapy

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中文摘要
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英文摘要
Trials of two new drugs, invermectin (Phase IIa) and CGP-20376 (Phase I), are being initiated in collaboration with investigators from Madras India for patients with bancroftian filariasis. Since bronchoalveolar lavage studies on patients with tropical pulmonary eosinophilia show persistent alveolitis despite standard therapy with diethylcarbamazine (DEC), a trial comparing long-term DEC or DEC plus steroids with standard therapy has commenced. Clinical evaluation of Peace Corps Volunteers working in Central/West Africa indicates that when such expatriates enter Loa loa endemic areas, they become immunologically hypersensitive to the parasite and often develop severe clinical symptoms. To develop means for protecting such individuals from infection, a double-blind trial of prophylactic weekly DEC is now in its second year.
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会议论文
STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS
STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS
STUDIES OF THE IMMUNOLOGIC RESPONSES TO FILARIAL INFECTIONS
STUDIES OF THE IMMUNOLOGICAL RESPONSES TO FILARIAL INFECTIONS
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