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CLINICAL AND THERAPEUTIC STUDIES IN HUMAN FILARIASIS

CLINICAL AND THERAPEUTIC STUDIES IN HUMAN FILARIASIS
人类丝虫病的临床和治疗研究
批准号：
3803184
负责人：
E A OTTESEN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3803184
关键词：
Africa Brazil Filarioidae India Wuchereria anthelmintics clinical trials drug screening /evaluation eosinophilia filariasis human subject human therapy evaluation human tissue parasitic disease chemotherapy

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英文摘要
Ivermectin has been shown in trials in both South India and elsewhere to be very effective in clearing microfilaremia in patients with bancroftian filariasis. Current studies in South India and Brazil (coordinated with trail elsewhere in the world) are focussed on developing a regimen to optimize the duration of microfilarial clearance. Recent investigation has indicated that the Tropical Pulmonary Eosinophilia syndrome can be caused by strongyloides as well as by filariae. Work to differentiate these two pulmonary eosinophilic conditions and develop appropriate therapy is underway. Loiasis in expatriate visitors to endemic areas has been characterized as having marked clinical and immunologic hyperresponsiveness to the filarial parasite. The hypothesized state of hyporesponsiveness, both clinical and immunological, in infected individuals native to the endemic regions has now been demonstrated by studies in Benin, West Africa. A therapeutic trial of albendazole for loiasis is also underway there.
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CLINICAL AND THERAPEUTIC STUDIES IN HUMAN FILARIASIS
STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS
STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS
STUDIES OF THE IMMUNOLOGIC RESPONSES TO FILARIAL INFECTIONS
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