STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS

实验钩虫（美洲钩虫）感染诱导， 正常志愿者，目标是定义 对蠕虫感染的免疫反应（特别是IgE）。 发现 50个丝状幼虫的小感染剂量能够 产生显著的短暂胃肠道疾病和显著的血液 嗜酸性粒细胞增多症，但诱导其他T细胞和B细胞依赖性免疫应答 其规模很小，难以评估 广泛地。 嗜酸性粒细胞结构和功能的明显变化 可以在感染过程中记录特征。 的 “低密度”嗜酸性粒细胞的比例增加了两到三倍， 感染，而产生超氧化物和迁移的能力 对趋化刺激的反应也显著增加。 的这些改变都是可以 仅限于嗜酸性粒细胞，在中性粒细胞中未见 人口

Experimental hookworm (Necator americanus) infections were induced in normal volunteers with a goal toward defining progressive changes in immunologic responses (especially IgE) to helminth infection. It was found that a small infecting dose of 50 filariform larvae was capable of producing significant transient gastrointestinal morbidity and marked blood eosinophilia but induced other T-cell and B-cell dependent immune responses that were of such low magnitude as to be difficult to evaluate extensively. Clear changes in eosinophil structural and functional profiles could be documented during the course of the infections. The proportion of 'hypodense' eosinophils increased two- to three-fold during infection while the capabilities of generating superoxide and of migrating to a chemotactic stimulus also increased significantly. Such changes were limited to eosinophils and were not seen in the neutrophil granulocyte population.