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STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS

STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS
非丝虫蠕虫感染的免疫反应研究
批准号：
3809589
负责人：
E A OTTESEN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3809589
关键词：
Platyhelminthes Schistosoma mansoni antibody formation blocking antibody egg /ovum fibrosis growth factor helminthic antigen human subject humoral immunity immunoglobulin E immunoglobulin G immunoglobulin isotypes immunology immunoregulation parasitic diseases parasitic liver disorder protein structure function schistosomiasis serology /serodiagnosis vascular endothelium

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英文摘要
Serial serum specimens collected 15 years ago from untreated patients with acute schistosomiasis mansoni have been previously studied for the evolution of their IgG and IgE antibody responses to different schistosome antigens. Because of the recently recognized importance of IgG4 antibodies both for diagnostic specificity and for blocking allergic reactions to the parasite, this unique collection of sera has been restudied to define the kinetics of a developing specific IgG4 antibody response. Interestingly, it appears that while antibodies of 1gG1, IgG2 and IgG3 subclasses develop within weeks of acute infection, specific IgG4 antibodies (to both egg and adult schistosome antigen) do not develop for 6-9 months after infection. This piece of information is of particular interest, since there are almost no other instances where the natural development of an IgG4 response in humans has been recorded.
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CLINICAL AND THERAPEUTIC STUDIES IN HUMAN FILARIASIS
STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS
STUDIES OF THE IMMUNOLOGIC RESPONSES TO FILARIAL INFECTIONS
STUDIES OF THE IMMUNOLOGICAL RESPONSES TO FILARIAL INFECTIONS
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