STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS

15年前从未经治疗的慢性阻塞性肺疾病患者身上收集的系列血清样本 以前对急性曼氏血吸虫病进行了研究 它们对不同血吸虫免疫球蛋白和免疫球蛋白E抗体应答的演变 抗原。因为最近人们认识到了IgG4抗体的重要性 既有诊断的特异性，也有阻断对 寄生虫，这一独特的血清集合已被重新研究，以定义 发育中特异性IgG4抗体反应的动力学。有趣的是，它 似乎随着1gG1、IgG2和IgG3亚类抗体的产生 在急性感染的几周内，特异性IgG4抗体(针对虫卵和 成虫抗原)在感染后6-9个月内不发育。 这条信息特别有意义，因为几乎有 没有其他情况下免疫球蛋白4应答的自然发展 人类已经被记录下来了。

Serial serum specimens collected 15 years ago from untreated patients with acute schistosomiasis mansoni have been previously studied for the evolution of their IgG and IgE antibody responses to different schistosome antigens. Because of the recently recognized importance of IgG4 antibodies both for diagnostic specificity and for blocking allergic reactions to the parasite, this unique collection of sera has been restudied to define the kinetics of a developing specific IgG4 antibody response. Interestingly, it appears that while antibodies of 1gG1, IgG2 and IgG3 subclasses develop within weeks of acute infection, specific IgG4 antibodies (to both egg and adult schistosome antigen) do not develop for 6-9 months after infection. This piece of information is of particular interest, since there are almost no other instances where the natural development of an IgG4 response in humans has been recorded.