STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL PARASITIC INFECTIONS

未经治疗的急性血吸虫病患者的系列血清标本 已经提供了直接的证据表明，慢性抗原刺激是 IgG 4反应在人类中发展所必需的。 尽管临床上 和免疫刺激，患者不能安装特异性IgG 4 感染后至少4-9个月的反应; 这种反应的开始与 感染 IgE和IgG 4反应的动力学似乎相似， 与其它IgG亚类的那些不同。 热带肺嗜酸性粒细胞增多综合征（TPE）通常由以下原因引起： 丝虫寄生虫，但最近的证据表明， 感染也可诱发临床上与TPE难以区分综合征。 正在进行详细的免疫学分析，以确定血清学诊断方法， 区分这两种临床症状。

Serial serum specimens from untreated patients with acute schistosomiasis have provided direct evidence that chronic antigenic stimulation is required for IgG4 responses to develop in humans. Despite intense clinical and immunological stimulation, patients were unable to mount specific IgG4 responses for at least 4-9 months after becoming infected; the rapidity of the onset of such responses was directly proportional to the intensity of infection. The kinetics of IgE and IgG4 responses appear similar and distinct from those of the other IgG subclasses. The tropical pulmonary eosinophilia syndrome (TPE) is generally caused by filarial parasites, but recent evidence indicates that strongyloides infection may also induce a syndrome clinically indistinguishable from TPE. Detailed immunologic analysis is underway to define serodiagnostic means to differentiate between these two clinical syndromes.