Enhancement of the soft tissue seal around transcutaneous implants and inhibition of bacterial colonisation

增强经皮植入物周围的软组织密封并抑制细菌定植

• 批准号: G1001942/1
• 负责人: Mukai ChimutengwendeGordon
• 金额: $ 26.96万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001942%2F1
• 关键词: Enhancement; soft; tissue; seal; around

Amputees are traditionally fitted with artificial limbs which are attached to amputation stumps by strapping or using suction sockets. The use of these artificial limbs may be complicated by sweating, rashes, ulceration and pressure sores due to uneven pressure distribution on the soft tissues of the stump. Osseointegrated prostheses used for amputees are bone-anchored metal implants that project through the skin to directly attach artificial limbs to the skeleton. Overall, amputees report improved quality of life, comfort, mobility and sensory awareness with these prostheses. However, infection is a significant problem as little attention has been paid to the seal between the soft tissues and the implant. The Intraosseous Transcutaneous Amputation Prosthesis (ITAP) is an exciting innovation developed at University College London that is designed to promote a tight soft tissue seal to prevent infection. This study aims to create a more robust seal by mimicking nature using a porous metal implant coated with hydroxyapatite (the mineral component in bone) and fibronectin (a naturally occurring protein) to enhance soft tissue attachment. Silver will be incorporated into the coating as it is known to reduce bacterial growth. The effect of these surfaces on skin cell attachment and bacterial growth will be tested.

截肢者传统上安装假肢，假肢通过捆绑或使用吸力插座连接到截肢残端。由于残肢软组织上的压力分布不均匀，使用这些假肢可能会出现出汗、皮疹、溃疡和压疮。用于截肢者的骨结合假体是骨锚定金属植入物，其穿过皮肤将假肢直接连接到骨骼上。总的来说，截肢者报告说，这些假肢改善了生活质量、舒适度、移动性和感官意识。然而，感染是一个重要的问题，因为很少注意到软组织和植入物之间的密封。骨内经皮截肢假体（ITAP）是伦敦大学学院开发的一项令人兴奋的创新，旨在促进紧密的软组织密封，以防止感染。本研究旨在通过使用涂覆有羟基磷灰石（骨中的矿物质成分）和纤连蛋白（一种天然存在的蛋白质）的多孔金属植入物来模拟自然，以增强软组织附着，从而创建更坚固的密封。将银掺入涂层中，因为已知银可减少细菌生长。将测试这些表面对皮肤细胞附着和细菌生长的影响。