Biomedical Catalyst – Demonstration of a low cost implantable blood pump

生物医学催化剂 — 低成本植入式血泵演示

• 批准号: MC_PC_13039
• 负责人: Catherine Thornton
• 金额: $ 36.32万
• 依托单位: Swansea University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_13039
• 关键词: Biomedical; Catalyst; Demonstration; low; cost

Advanced heart failure is a large and growing healthcare challenge not adequately met by traditional medical management, cardiac resynchronisation or transplantation. Ventricular assist devices (VADs) can address this need and have shown very promising clinical results. However, existing VADs are expensive, have high utilisation costs due to significant complications and require extensive invasive surgery for implantation. Calon’s MiniVAD addresses these problems with a smaller pump, reduced blood damage and significantly improved health economics. This project proposes the development of novel blood damage assays and the subsequent detailed in-vitro and in-vivo evaluation of the MiniVAD to provide the performance and safety data necessary to support a regulatory application to begin human clinical studies.

晚期心力衰竭是一个巨大且日益增长的医疗保健挑战，传统的医疗管理、心脏再同步或移植无法充分满足这一挑战。心室辅助装置（VADs）可以满足这一需求，并显示出非常有希望的临床结果。然而，现有的VADs价格昂贵，由于严重的并发症，使用成本高，并且需要广泛的侵入性手术来植入。Calon的MiniVAD用更小的泵解决了这些问题，减少了血液损伤，显著提高了健康经济性。该项目建议开发新的血液损伤检测方法，并随后对MiniVAD进行详细的体外和体内评估，以提供必要的性能和安全性数据，以支持开始人体临床研究的监管申请。

项目成果

The CentriMag centrifugal blood pump as a benchmark for in vitro testing of hemocompatibility in implantable ventricular assist devices.

• DOI: 10.1111/aor.12351
• 发表时间: 2015-02
• 期刊: Artificial organs
• 影响因子: 2.4
• 作者: Chan CH;Pieper IL;Hambly R;Radley G;Jones A;Friedmann Y;Hawkins KM;Westaby S;Foster G;Thornton CA
• 通讯作者: Thornton CA

Isolation of Mesenchymal Stromal Cells From Peripheral Blood of ST Elevation Myocardial Infarction Patients

• DOI: 10.1111/aor.12829
• 发表时间: 2017-02
• 期刊: Artificial Organs
• 影响因子: 2.4
• 作者: I. L. Pieper;Rachel Smith;J. Bishop;O. Aldalati;Alexander J Chase;G. Morgan;C. Thornton

Ovine Leukocyte Microparticles Generated by the CentriMag Ventricular Assist Device In Vitro.

CentriMag 心室辅助装置在体外产生的绵羊白细胞微粒。

• DOI: 10.1111/aor.13068
• 发表时间: 2018
• 期刊: Artificial organs
• 影响因子: 2.4
• 作者: Pieper IL

The Inflammatory Response to Ventricular Assist Devices.

• DOI: 10.3389/fimmu.2018.02651
• 发表时间: 2018
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Radley G;Pieper IL;Ali S;Bhatti F;Thornton CA
• 通讯作者: Thornton CA

In Vitro Benchmarking Study of Ventricular Assist Devices in Current Clinical Use.

当前临床使用的心室辅助装置的体外基准研究。

• 发表时间: 2019
• 期刊: Journal of Cardiac Failure
• 影响因子: 6
• 作者: Gemma Radley;I. L. Pieper;C. R. Robinson;Sabrina Alì;Mostafa Beshr;O. Bodger;C. Thornton
• 通讯作者: C. Thornton