The Avon Longitudinal Study of Parents and Children: An international resource for populationgenomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019

20多年来，90年代儿童(或ALSPAC)绘制了14,500名父母和儿童的健康图表。现在已经进入第三个十年，它已经开始研究下一代，90年代孩子的孩子。这项研究无法与其他人口研究相提并论，因为它掌握了从20多年前出生前到现在参与者的广泛而深入的信息。它在国际上享有盛誉，并被世界各地的研究人员使用。这些数据让研究人员能够研究发育的关键时期，某些疾病是如何发展和变化的，是如何代代相传的(或不是)，以及基因和其他因素之间的相互作用是如何影响健康的，比如吸烟，人们住在哪里，他们从事的工作。我们的目标是确保资源保持可持续发展，开放给研究人员使用，并确保参与者保持参与。我们将继续通过临床评估、问卷调查和记录联系从原始儿童那里收集信息，并将招募和收集儿童儿童的数据，并合并遗传数据，加强在令人兴奋的表观基因组学新领域的研究。

For over 20 years Children of the 90s (or ALSPAC) has charted the health of 14,500 parents andchildren. Now in its third decade it has started to study the next generation, the children of theChildren of the 90s. The study is unequalled by other population studies because of the breadthand depth of information it holds on participants from before birth over 20 years ago through to thepresent day. It is internationally renowned and used by researchers worldwide. The data allowresearchers to study key periods of development, how certain conditions develop and change overtime and are passed (or not) from one generation to the next, and how health is affected by theinterplay between genes and other factors like smoking, where people live and the job they do.Our goals are to ensure the resource remains sustainable and open to researchers to use, andthat participants remain engaged. We will continue to gather information from the original childrenthrough clinical assessments, questionnaires and record linkage, and will be recruiting andgathering data on the children of the children as well as merging genetic data and enhancing research in the exciting new field of epigenomics.