The Avon Longitudinal Study of Parents and Children: An international resource for populationgenomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019

雅芳父母和儿童纵向研究：人口基因组学和生命历程流行病学的国际资源。

• 批准号: MC_PC_15018
• 负责人: Nicholas Timpson
• 金额: $ 903.84万
• 依托单位: Wellcome Trust
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_15018
• 关键词: Avon; Longitudinal; Study; Parents; Children

For over 20 years Children of the 90s (or ALSPAC) has charted the health of 14,500 parents andchildren. Now in its third decade it has started to study the next generation, the children of theChildren of the 90s. The study is unequalled by other population studies because of the breadthand depth of information it holds on participants from before birth over 20 years ago through to thepresent day. It is internationally renowned and used by researchers worldwide. The data allowresearchers to study key periods of development, how certain conditions develop and change overtime and are passed (or not) from one generation to the next, and how health is affected by theinterplay between genes and other factors like smoking, where people live and the job they do.Our goals are to ensure the resource remains sustainable and open to researchers to use, andthat participants remain engaged. We will continue to gather information from the original childrenthrough clinical assessments, questionnaires and record linkage, and will be recruiting andgathering data on the children of the children as well as merging genetic data and enhancing research in the exciting new field of epigenomics.

20多年来，90年代儿童（或ALSPAC）绘制了14,500名父母和儿童的健康图表。现在已经是第三个十年了，它开始研究下一代，90后的孩子们。这项研究是其他人口研究无法比拟的，因为它掌握了参与者从20多年前出生前到现在的信息的广度和深度。它在国际上享有盛誉，并被世界各地的研究人员使用。这些数据使研究人员能够研究发育的关键时期，某些条件是如何随着时间的推移而发展和变化的，并且是如何代代相传的，以及基因和其他因素（如吸烟、居住地点和工作）之间的相互作用是如何影响健康的。我们的目标是确保资源保持可持续性，并向研究人员开放使用，并确保参与者保持参与。我们将继续通过临床评估、问卷调查和记录链接来收集原患儿的信息，并将招募和收集这些患儿的子女的数据，以及合并遗传数据并加强表观基因组学这一令人兴奋的新领域的研究。

项目成果

The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study.

• DOI: 10.1016/j.ajhg.2022.05.005
• 发表时间: 2022-07-07
• 期刊: American journal of human genetics
• 影响因子: 9.8

Intelligence in offspring born to women exposed to intimate partner violence: a population-based cohort study.

• DOI: 10.12688/wellcomeopenres.15270.1
• 发表时间: 2019-01-01
• 期刊: Wellcome open research
• 作者: Abel, Kathryn M;Heuvelman, Hein;Emsley, Richard
• 通讯作者: Emsley, Richard

Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children.

• DOI: 10.1002/ajmg.b.32924
• 发表时间: 2023-07
• 期刊: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
• 影响因子: 2.8
• 作者: Abdulkadir, Mohamed;Tischfield, Jay A.;Heiman, Gary A.;Hoekstra, Pieter J.;Dietrich, Andrea
• 通讯作者: Dietrich, Andrea

Association of maternal pre-pregnancy BMI and breastfeeding with NAFLD in young adults: a parental negative control study.

• DOI: 10.1016/j.lanepe.2021.100206
• 发表时间: 2021-11
• 期刊: The Lancet regional health. Europe
• 作者: Abeysekera KW;Orr JG;Madley-Dowd P;Fernandes GS;Zuccolo L;Gordon FH;Lawlor DA;Heron J;Hickman M
• 通讯作者: Hickman M

Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.

• DOI: 10.1002/erv.2889
• 发表时间: 2022-05
• 期刊: EUROPEAN EATING DISORDERS REVIEW
• 影响因子: 5.3
• 作者: Abdulkadir, Mohamed;Huebel, Christopher;Herle, Moritz;Loos, Ruth J. F.;Breen, Gerome;Bulik, Cynthia M.;Micali, Nadia
• 通讯作者: Micali, Nadia