The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource

雅芳父母和儿童纵向研究 (ALSPAC)：多代纵向资源

• 批准号: MC_PC_19009
• 负责人: Nicholas Timpson
• 金额: $ 530.53万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_19009
• 关键词: Avon; Longitudinal; Study; Parents; Children

"Between April 1991 and December 1992 we enrolled >14000 pregnant women in ALSPAC resulting in 14062 live births. Mothers, fathers, children and now children of the children from this recruitment have been followed up at multiple timepoints and a wide variety of samples, exposure and outcome measures collected.Our mission is to ensure ALSPAC remains the premier multi-generational birth cohort offering unrivalled access to data and samples. We will look after the existing samples and data, improve visibility and access to the existing resource, maximise the connection of administrative data and continue collecting new data and samples.Maintaining such a valuable UK resource will enable research uniquely equipped to follow changes in health and well-being across the lifespan, what affects this, how certain factors work across generations, and how changes in society affect the health and well-being of families going through similar events 30 years apart."

“1991年4月至1992年12月，我们在ALSPAC登记了14 000多名孕妇，结果有14 062名活产婴儿。我们在多个时间点对此次招募的母亲、父亲、孩子以及孩子的孩子进行了跟踪，并收集了各种样本、暴露和结果指标。我们的使命是确保ALSPAC仍然是首屈一指的多代出生队列，提供无与伦比的数据和样本访问。我们将照顾现有的样本和数据，提高现有资源的可见性和访问性，最大限度地提高管理数据的连接，并继续收集新的数据和样本。维护这样一个宝贵的英国资源将使研究能够独特地跟踪整个生命周期中健康和福祉的变化，是什么影响了这一点，某些因素如何在几代人之间起作用，以及社会的变化如何影响相隔30年经历类似事件的家庭的健康和福祉。"

项目成果

Intelligence in offspring born to women exposed to intimate partner violence: a population-based cohort study.

• DOI: 10.12688/wellcomeopenres.15270.1
• 发表时间: 2019-01-01
• 期刊: Wellcome open research
• 作者: Abel, Kathryn M;Heuvelman, Hein;Emsley, Richard
• 通讯作者: Emsley, Richard

Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children.

• DOI: 10.1002/ajmg.b.32924
• 发表时间: 2023-07
• 期刊: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
• 影响因子: 2.8
• 作者: Abdulkadir, Mohamed;Tischfield, Jay A.;Heiman, Gary A.;Hoekstra, Pieter J.;Dietrich, Andrea
• 通讯作者: Dietrich, Andrea

Association of maternal pre-pregnancy BMI and breastfeeding with NAFLD in young adults: a parental negative control study.

• DOI: 10.1016/j.lanepe.2021.100206
• 发表时间: 2021-11
• 期刊: The Lancet regional health. Europe
• 作者: Abeysekera KW;Orr JG;Madley-Dowd P;Fernandes GS;Zuccolo L;Gordon FH;Lawlor DA;Heron J;Hickman M
• 通讯作者: Hickman M

Evaluating future risk of NAFLD in adolescents: a prediction and decision curve analysis.

• DOI: 10.1186/s12876-022-02401-y
• 发表时间: 2022-06-30
• 期刊: BMC GASTROENTEROLOGY
• 影响因子: 2.4
• 作者: Abeysekera, Kushala W. M.;Orr, James G.;Gordon, Fiona H.;Howe, Laura D.;Hamilton-Shield, Julian;Heron, Jon;Hickman, Matthew
• 通讯作者: Hickman, Matthew

The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study.

• DOI: 10.1016/j.ajhg.2022.05.005
• 发表时间: 2022-07-07
• 期刊: American journal of human genetics
• 影响因子: 9.8