BIOLOGICAL STUDIES OF HUMAN PITUITARY TUMORS

人类垂体肿瘤的生物学研究

• 批准号: 4696883
• 负责人: E H OLDFIELD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696883
• 关键词: Cushing's syndrome; X ray spectrometry; acromegaly; biopsy; blood chemistry; chemical conjugate; corticotropin releasing factor; cytotoxicity; electron microscopy; endocrine disorder diagnosis; endocrine pharmacology; gonadotropin releasing factor; histopathology; hormone regulation /control mechanism; human tissue; hypothalamic pituitary axis; image processing; immunochemistry; immunoperoxidase; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; neoplasm /cancer therapy; neoplastic growth; peptide hormone biosynthesis; pituitary gland; pituitary hormones; pituitary neoplasms; prognosis; radioimmunoassay; scanning electron microscopy; secretion; tissue /cell culture; toxin

The influence of the hypothalamic releasing factors CRF and GRF on the hormonal secretion of pituitary adenomas has been determined in vitro and correlated with the patients' response in vivo. These studies indicate that the pituitary tumors causing Cushing's disease, Nelson's Syndrome and acromegaly are responsive to their appropriate releasing factor. We are investigating the potential of using the releasing factors conjugated to toxic proteins to effect cytotoxicity of pituitary tumors in vitro. The preliminary results are encouraging. We have also investigated the use of venous sampling to aid in the diagnosis and treatment of patients with Cushing's syndrome. Our results, which now include 55 patients with Cushing's syndrome, suggest that the procedure will be of significant benefit in: 1) establishing the diagnosis of Cushing's disease and 2) determining preoperatively the site of pituitary microadenomas.

下丘脑释放因子CRF和GRF对大鼠血压的影响 垂体腺瘤的激素分泌已在体外和 与患者在体内的反应有关。这些研究表明 引起库欣病、纳尔逊综合征和脑下垂体瘤的 肢端肥大症对其适当的释放因子有反应。我们是 研究结合释放因子的潜在用途 毒性蛋白对体外培养的垂体瘤细胞毒性的影响。这个 初步结果令人鼓舞。 我们还调查了静脉采样的使用情况，以帮助 库欣综合征的诊断和治疗。我们的结果， 现在包括55名库欣综合征患者，这表明 该程序将在以下方面有显著的益处：1)建立诊断 2)术前确定肿瘤的位置。 脑下垂体微腺瘤。