BIOLOGICAL STUDIES OF HUMAN PITUITARY TUMORS

人类垂体肿瘤的生物学研究

• 批准号: 3968976
• 负责人: E H OLDFIELD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3968976
• 关键词: Cushing's syndrome; acromegaly; biopsy; blood chemistry; chemical conjugate; corticotropin releasing factor; cytotoxicity; endocrine disorder diagnosis; endocrine pharmacology; gonadotropin releasing factor; histopathology; hormone regulation /control mechanism; human tissue; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; neoplasm /cancer therapy; peptide hormone biosynthesis; pituitary gland; pituitary neoplasms; prognosis; secretion; tissue /cell culture; toxin

The influence of the hypothalamic releasing factors CRF and GRF on the hormonal secretion of pituitary adenomas has been determined in vitro and correlated with the patient's response in vivo. These studies indicate that the pituitary tumors causing Cushing's disease, Nelson's Syndrome and acromegaly are responsive to their appropriate releasing factor. We are investigating the potential of using releasing factors conjugated to toxic proteins to effect cytotoxicity of pituitary tumors in vitro. We have investigated the use of venous sampling to aid in the diagnosis and treatment of patients with Cushing's Syndrome. Our results, which now include 89 patients with Cushing's Syndrome, suggest that the procedure will be of significant benefit in: 1) establishing the diagnosis of Cushing's disease and 2) determining preoperatively the site of pituitary microadenomas.

下丘脑释放因子CRF和GRF对大鼠脑缺血再灌注损伤的影响 垂体腺瘤的激素分泌已经在体外测定， 与患者体内反应相关。 这些研究表明 引起库欣病、纳尔逊综合征和 肢端肥大症对它们适当的释放因子有反应。 我们 研究使用与毒性结合的释放因子的潜力， 蛋白质以影响体外垂体肿瘤的细胞毒性。 我们已经研究了静脉取样的使用，以帮助诊断， 治疗患有库欣综合征的患者。 我们的结果，现在 包括89例库欣综合征患者，表明该手术 将在以下方面具有显著的益处：1）建立诊断 库欣病; 2）术前确定垂体位置 微腺瘤