INVESTIGATION OF CENTRAL NERVOUS SYSTEM VASCULAR DISORDERS

中枢神经系统血管疾病的调查

• 批准号: 3945324
• 负责人: E H OLDFIELD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3945324
• 关键词: blood flow measurement; blood pressure; cardiovascular disorder diagnosis; cerebral hemorrhage; cerebrovascular disorders; cerebrovascular imaging /visualization; congenital arteriovenous shunt; hemodynamics; heterodyning; human subject; myelinopathy; spinal cord disorders; spinal cord imaging /visualization

The clinical features, arteriographic findings, and treatment of 81 patients with spinal arteriovenous malformations demonstrated that there are distinguishing clinical features in patients with arteriovenous malformations of the spinal cord compared to those of patients with arteriovenous fistulas of the spinal dura. The findings indicate that spinal arteriovenous fistulas are acquired lesions, and not congenital, as was previously thought, and support arteriovenous malformations of the spinal cord as congenital lesions. The findings also indicate that AVMs of the spinal cord produce myelopathy as a result of high flow and that the associated arterial steal and the multiple hemorrhages experienced by these patients result from the rapid flow through the lesions, whereas patients with spinal dural AV fistulas develop myelopathy as a result of increased venous pressure in the spinal cord. Magnetic resonance imaging permits demonstration of the presence and site of arteriovenous malformations of the spinal cord and therefore is a valuable and safe, non-invasive technique to investigate patients suspected of having spinal AVMs. Laser Doppler velocimetry can be used to monitor microcirculatory flow in the brain intraoperatively in patients with cerebral arteriovenous malformations. The results from using this procedure in one such patient demonstrate that the excision of the AVM leads to a prominent increase in cerebral blood flow in the tissue adjacent to the AVM and support the presence of a transient loss of brain vasoregulation in this tissue.

81例原发性高血压的临床特点、动脉造影表现及治疗 脊髓动静脉畸形患者证实 有区别的临床特征， 脊髓动静脉畸形与 硬脊膜动静脉瘘的患者。 的 研究结果表明，脊髓动静脉瘘是后天性的， 病变，而不是先天性的，因为以前认为，和支持 先天性脊髓动静脉畸形 病变 研究结果还表明，脊髓AVM 由于高流量而产生脊髓病， 相关动脉盗血和多发性动脉瘤 这些患者所经历的由快速流过 病变，而患有硬脊膜动静脉瘘的患者 脊髓病是由于脊髓中的静脉压增加 线. 磁共振成像可以证明 脊髓动静脉畸形的存在和部位 因此是一种有价值的安全的非侵入性技术 调查疑似患有脊柱动静脉畸形的患者。 激光多普勒测速仪可用于监测 患者术中脑内微循环血流 脑动静脉畸形 的结果 在一个这样的患者中使用该程序证明， 切除AVM会导致脑内 AVM附近组织中的血流，并支持 该组织中存在短暂的脑血管调节丧失。