PENTOBARBITAL EFFECTS ON BRAIN DAMAGE BY FRACTIONATED WHOLE BRAIN RADIATION

戊巴比妥对分段全脑辐射造成的脑损伤的影响

• 批准号: 5203955
• 负责人: E H OLDFIELD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5203955
• 关键词: Macaca mulatta; brain electrical activity; brain injury; brain metabolism; brain neoplasms; combination cancer therapy; histopathology; ketamine; magnetic resonance imaging; neoplasm /cancer radiation therapy; neuroendocrine system; nonhuman therapy evaluation; pentobarbital; radiation hazard; radiation protection; radiation therapy dosage

Radiation therapy remains the single most effective treatment for malignant brain tumors, but in many cases, toxicity to normal brain impedes therapeutic doses sufficient for local control to be achieved. A substantial effort has been directed toward overcoming the unfavorable side effects of brain tumor radiation therapy. Small animal studies in our Branch indicate that pentobarbital anesthesia during cerebral irradiation reduces the toxicity of the ionizing radiation. Although mechanisms of this phenomenon remain unclear, it may arise from suppression of brain synaptic activity or metabolism. After baseline MRI scans of the brain and neuroendocrine testings, primates (Macaca mulatta) underwent whole brain X-irradiation in 10 daily fractions, 360 rads each (total dose of 3600 rads). The monkeys in the study group were anesthetized with pentobarbital during the irradiation, whereas the animals in the control group received ketamine. Each group consists of 6 animals. Neuroendocrine testing and MRI scan follow-up studies are performed at 3, 6 12, 18 and 24 months after irradiation to detect potential differences in the degree of brain injury in the two groups.

放射治疗仍然是最有效的单一治疗方法 恶性脑肿瘤，但在许多情况下，对正常大脑有毒性 阻碍足以实现局部控制的治疗剂量。 为克服不利因素付出了巨大的努力 脑肿瘤放射治疗的副作用。小动物研究 我们的部门表明，戊巴比妥麻醉在脑 辐射降低了电离辐射的毒性。虽然 这种现象的机制尚不清楚，可能是由于 抑制大脑突触活动或新陈代谢。基线 MRI 后 大脑扫描和神经内分泌测试，灵长类动物（Macaca mulatta） 每天分 10 次进行全脑 X 射线照射，每次 360 拉德 （总剂量为 3600 拉德）。研究组中的猴子是 在照射过程中用戊巴比妥麻醉，而 对照组的动物接受氯胺酮。每组由 6 只动物。 神经内分泌测试和 MRI 扫描随访研究 在照射后3、6、12、18和24个月进行检测 两组脑损伤程度的潜在差异。