DEVELOPMENT OF ENZYMES THAT INACTIVATE NEUROTOXIC AGENTS

灭活神经毒剂的酶的开发

• 批准号: 4696902
• 负责人: R O BRADY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696902
• 关键词: detoxification; neurotoxins; poison control; soil microbiology

An enzyme that degrades barbital has been identified and partially purified from extracts derived from a soil micro-organism. The requirements for maximal catalytic activity are being determined. We attempted to scale-up the production of this enzyme to examine its effectiveness in reversing the effects of lethal quantities of barbital in toxicological experiments with appropriate animals.

一种降解巴比妥的酶已被鉴定并部分纯化 来自土壤微生物的提取物。 要求 最大催化活性正在确定。 我们尝试扩大规模 生产这种酶以检查其逆转疾病的有效性 巴比妥在毒理学实验中致死量的影响 合适的动物。