课题基金 / 基金详情

MODIFICATION OF BRAIN SPECIFIC CYCLIN DEPENDENT KINASE GENES

MODIFICATION OF BRAIN SPECIFIC CYCLIN DEPENDENT KINASE GENES
脑特异性细胞周期蛋白依赖性激酶基因的修饰
批准号:
6111916
负责人:
R O BRADY
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:

项目摘要

项目成果

R O BRADY的其他基金

相似基金

相关文献

中文摘要
翻译
cdc5蛋白激酶家族起着重要作用
英文摘要
The cdc5 family of protein kinases has a major role in the regulation of the cell cycle in eukaryotes. In order to determine the role of the cdk5 in brain development, we created cdk5 knock-out (-/-) mice. The life-span of these mice was greatly shortened. The brains of these mice lack cortical laminar structure and cerebellar foliation. Recent studies revealed that the Cdk5 (-/-) thalamic axons project through the cerebral cortex with abnormal trajectories and cortical plate neurons were inverted according to their birth date. The cells of the preplate were separated into subplate and marginal zone by neurons with the morphology of normal pyramidal neurons. Some of the axons of these cells projected correctly to the thalamic anlage. The results suggest that further cortical development is blocked in the Cdk5 (-/-) mice at an intermediate stage soon after the splitting of the preplate. Comparison with Cdk5 (-/-) with reeler and scrambler mice indicates that the cdk5 deficiency causes distinct pathological changes. The results suggest that Cdk5 participates in a separate, perhaps parallel, pathway of brain development.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
GENE THERAPY OF INHERITED ENZYME DEFICIENCIES
ENZYME REPLACEMENT THERAPY IN DISORDERS THAT AFFECT THE CENTRAL NERVOUS SYSTEM
ENZYME REPLACEMENT THERAPY IN DISORDERS THAT AFFECT THE CENTRAL NERVOUS SYSTEM
ENZYME REPLACEMENT THERAPY IN AN ANALOGUE OF HUMAN GM1 GANGLIOSIDOSIS
海外基金