Phase 1 COVID-19 Immunity - National Core Study

COVID-19 免疫第一阶段 - 国家核心研究

• 批准号: MC_PC_20060
• 负责人: Paul Moss
• 金额: $ 999.65万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_20060
• 关键词: Phase; COVID; 19; Immunity; National

The magnitude and quality of a person's immune response remains a central determinant of clinical outcome following SARS-CoV-2 infection and vaccines now provide an approach for pandemic control. The NCSi programme is designed to co-ordinate and build on UK investments in understanding COVID-19 immunity. These are based around four themes which seek to predict and manage individual risk, protect against acute infection and late effects of infection, prevent primary infection or re-infection, and prepare for future pandemic challenges.

一个人的免疫反应的程度和质量仍然是SARS-CoV-2感染后临床结果的核心决定因素，疫苗现在提供了一种控制大流行的方法。NCSi计划旨在协调和建立英国在了解COVID-19免疫方面的投资。这四个主题旨在预测和管理个人风险，预防急性感染和感染的后期影响，预防初次感染或再次感染，并为未来的大流行挑战做好准备。

项目成果

HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19.

• DOI: 10.1111/imm.13450
• 发表时间: 2022-05
• 期刊: Immunology
• 影响因子: 6.4

COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study.

• DOI: 10.1016/s2468-1253(22)00005-x
• 发表时间: 2022-04
• 期刊: The lancet. Gastroenterology & hepatology
• 作者: Alexander JL;Kennedy NA;Ibraheim H;Anandabaskaran S;Saifuddin A;Castro Seoane R;Liu Z;Nice R;Bewshea C;D'Mello A;Constable L;Jones GR;Balarajah S;Fiorentino F;Sebastian S;Irving PM;Hicks LC;Williams HRT;Kent AJ;Linger R;Parkes M;Kok K;Patel KV;Teare JP;Altmann DM;Boyton RJ;Goodhand JR;Hart AL;Lees CW;Ahmad T;Powell N;VIP study investigators
• 通讯作者: VIP study investigators

Risk of severe COVID-19 outcomes after autumn 2022 COVID-19 booster vaccinations: a pooled analysis of national prospective cohort studies involving 7.4 million adults in England, Northern Ireland, Scotland and Wales.

• DOI: 10.1016/j.lanepe.2023.100816
• 发表时间: 2024-02
• 期刊: LANCET REGIONAL HEALTH-EUROPE
• 影响因子: 20.9
• 作者: Bedston, Stuart;Almaghrabi, Fatima;Patterson, Lynsey;Agrawal, Utkarsh;Woolford, Lana;Anand, Sneha N;Joy, Mark;Crawford, Anna;Goudie, Rosalind;Byford, Rachel;Abbasizanjani, Hoda;Smith, Deb;Laidlaw, Lynn;Akbari, Ashley;Sullivan, Christopher;Bradley, Declan T;Lyons, Ronan A;de Lusignan, Simon;Hobbs, F D Richard;Robertson, Chris;Sheikh, Sir Aziz;Shi, Ting
• 通讯作者: Shi, Ting

COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective, case-control study.

• DOI: 10.1016/s2468-1253(22)00274-6
• 发表时间: 2022-11
• 期刊: LANCET GASTROENTEROLOGY & HEPATOLOGY
• 影响因子: 35.7
• 作者: Alexander, James L.;Liu, Zhigang;Sandoval, Diana Munoz;Reynolds, Catherine;Ibraheim, Hajir;Anandabaskaran, Sulak;Saifuddin, Aamir;Seoane, Rocio Castro;Anand, Nikhil;Nice, Rachel;Bewshea, Claire;D'Mello, Andrea;Constable, Laura;Jones, Gareth R.;Balarajah, Sharmili;Fiorentino, Francesca;Sebastian, Shaji;Irving, Peter M.;Hicks, Lucy C.;Williams, Horace R. T.;Kent, Alexandra J.;Linger, Rachel;Parkes, Miles;Kok, Klaartje;Patel, Kamal V.;Teare, Julian P.;Altmann, Daniel M.;Goodhand, James R.;Hart, Ailsa L.;Lees, Charlie W.;Boyton, Rosemary J.;Kennedy, Nicholas A.;Ahmad, Tariq;Powell, Nick
• 通讯作者: Powell, Nick

Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN study.

• DOI: 10.1016/j.jinf.2022.09.004
• 发表时间: 2022-11
• 期刊: JOURNAL OF INFECTION
• 影响因子: 28.2
• 作者: Atti, Ana;Insalata, Ferdinando;Carr, Edward J.;Otter, Ashley D.;Castillo-Olivares, Javier;Wu, Mary;Harvey, Ruth;Howell, Michael;Chan, Andrew;Lyall, Jonathan;Temperton, Nigel;Cantoni, Diego;da Costa, Kelly;Nadesalingam, Angalee;Taylor-Kerr, Andrew;Hettiarachchi, Nipunadi;Tranquillini, Caio;Hewson, Jacqueline;Cole, Michelle J.;Foulkes, Sarah;Munro, Katie;Monk, Edward J. M.;Milligan, Iain D.;Linley, Ezra;Chand, Meera A.;Brown, Colin S.;Islam, Jasmin;Semper, Amanda;Charlett, Andre;Heeney, Jonathan L.;Beale, Rupert;Zambon, Maria;Hopkins, Susan;Brooks, Tim;Hall, Victoria
• 通讯作者: Hall, Victoria