Life course methods and functional trajectories

生命过程方法和功能轨迹

• 批准号: MC_UU_00019/4
• 负责人: Nishi Chaturvedi
• 金额: $ 107.42万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00019%2F4
• 关键词: Life; course; methods; functional; trajectories

It is clear that both protective and adverse risk factors operate throughout life to cause disease and disability. But whether these factors are cumulative, or if their rate of change is particularly important, is still unclear. By understanding the trajectories of risk factors i.e how they operate across life and interact with each other, we can better identify periods in life which are particularly important to cause disease, and where interventions may have the greatest potential for benefit.

很明显，保护性和不利的风险因素在人的一生中都起作用，造成疾病和残疾。但是，这些因素是否是累积的，或者它们的变化率是否特别重要，仍然不清楚。通过了解风险因素的轨迹，即它们如何在生命中发挥作用并相互作用，我们可以更好地确定生命中对导致疾病特别重要的时期，以及干预措施可能具有最大的受益潜力的时期。

项目成果

Myocardial strain by 3D-speckle tracking echocardiography predicts long-term risk of cardiovascular morbidity and mortality in the general population: the Southall And Brent Revisited (SABRE) study

3D 斑点追踪超声心动图的心肌应变可预测一般人群心血管发病和死亡的长期风险：索撒尔和布伦特重访 (SABRE) 研究

• DOI: 10.1093/eurheartj/ehab724.067
• 发表时间: 2021
• 期刊: European Heart Journal
• 影响因子: 39.3
• 作者: Al Saikhan L

Relationship Between Image Quality and Bias in 3D Echocardiographic Measures: Data From the SABRE (Southall and Brent Revisited) Study.

• DOI: 10.1161/jaha.120.019183
• 发表时间: 2022-05-03
• 期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• 影响因子: 5.4
• 作者: Al Saikhan, Lamia;Park, Chloe;Tillin, Therese;Lloyd, Guy;Mayet, Jamil;Chaturvedi, Nish;Hughes, Alun D.
• 通讯作者: Hughes, Alun D.

Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study.

• DOI: 10.3389/fcvm.2020.591946
• 发表时间: 2020
• 期刊: Frontiers in cardiovascular medicine
• 影响因子: 3.6
• 作者: Al Saikhan L;Alobaida M;Bhuva A;Chaturvedi N;Heasman J;Hughes AD;Jones S;Eastwood S;Manisty C;March K;Ghosh AK;Mayet J;Oguntade A;Tillin T;Williams S;Wright A;Park C
• 通讯作者: Park C

Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study

• DOI: 10.1016/s0140-6736(23)00131-9
• 发表时间: 2023-04-06
• 期刊: LANCET
• 影响因子: 168.9
• 作者: Allinson, James Peter;Chaturvedi, Nishi;Hardy, Rebecca
• 通讯作者: Hardy, Rebecca