Physiological resilience: mechanisms and consequences

生理弹性：机制和后果

• 批准号: MC_UU_00019/2
• 负责人: Nishi Chaturvedi
• 金额: $ 227.32万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00019%2F2
• 关键词: Physiological; resilience; mechanisms; consequences

Resilience, the ability to ‘bounce back’ from a challenge, gets worse with age. For example, older people are less likely to make a full recovery to their pre-illness state from a fall, infection or surgery. This is also true for the response to daily life challenges; for example, older people lose the ability to prevent the fall in blood pressure on standing, and their blood pressure subsequently takes longer to return to normal, than younger people. Similarly, levels of circulating glucose (a simple sugar) in response to a meal takes longer to return to normal in older than younger people. We suggest that loss of resilience is an early marker of poor outcomes, specifically progressive loss of function, increased risk of disease, frailty and death. We will measure responses to controlled stressors in the clinic (e.g. standing up, physical activity, thinking). This will allow us to determine if a person shows early signs that they will be at more risk of disease and disability in the future. Potentially, we could use measures of resilience to identify people at high risk and may find new ways to intervene to improve their resilience which would lead to better outcomes.

弹性，从挑战中“反弹”的能力，随着年龄的增长而变差。例如，老年人不太可能从跌倒、感染或手术中完全恢复到患病前的状态。对于应对日常生活挑战也是如此;例如，老年人失去了防止站立时血压下降的能力，他们的血压随后需要比年轻人更长的时间才能恢复正常。同样，老年人的循环葡萄糖（一种简单的糖）水平对一顿饭的反应比年轻人需要更长的时间才能恢复正常。我们认为，恢复力的丧失是不良结局的早期标志，特别是进行性功能丧失、疾病风险增加、虚弱和死亡。我们将测量对诊所中受控压力源的反应（例如站立，体力活动，思考）。这将使我们能够确定一个人是否表现出早期迹象，表明他们将来患疾病和残疾的风险更大。潜在地，我们可以使用弹性的措施来识别高风险的人，并可能找到新的干预方法来提高他们的弹性，这将导致更好的结果。

项目成果

Little genomic support for cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in APOE4 carriers

亲环蛋白 A-基质金属蛋白酶-9 通路作为 APOE4 携带者认知障碍的治疗靶点的基因组支持很少

• DOI: 10.1101/2021.04.22.21255729
• 发表时间: 2021
• 作者: Anderson E

Lower respiratory tract infections in early childhood - Authors' reply.

儿童早期的下呼吸道感染 - 作者的回复。

• DOI: 10.1016/s0140-6736(23)01620-3
• 发表时间: 2023
• 期刊: Lancet (London, England)
• 作者: Allinson JP

Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study

• DOI: 10.1016/s0140-6736(23)00131-9
• 发表时间: 2023-04-06
• 期刊: LANCET
• 影响因子: 168.9
• 作者: Allinson, James Peter;Chaturvedi, Nishi;Hardy, Rebecca
• 通讯作者: Hardy, Rebecca

Little genomic support for Cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in APOE4 carriers.

• DOI: 10.1038/s41598-022-05225-8
• 发表时间: 2022-01-20
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Anderson EL;Williams DM;Walker VM;Davies NM
• 通讯作者: Davies NM

Polygenic and socioeconomic risk for high body mass index: 69 years of follow-up across life.

• DOI: 10.1371/journal.pgen.1010233
• 发表时间: 2022-07
• 期刊: PLoS genetics
• 影响因子: 4.5