Persistent Infections

持续感染

• 批准号: MC_UU_12014/3
• 负责人: Massimo Palmarini
• 金额: $ 394.87万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12014%2F3
• 关键词: Persistent; Infections

Congenital, Genital and Transplant-Acquired Infections – Genomics of Human CytomegalovirusDr Andrew Davison, Lead Investigator, in collaboration with Prof Sheila Graham and Prof Ruth Jarrett, MRC-University of Glasgow Centre for Virus Research (CVR), University of Glasgow.Human cytomegalovirus (HCMV) can be a serious issue for people whose immune systems are immature or not working properly. It is a major cause of foetal infections, a leading cause of illness in transplant recipients, and a problem for AIDS patients.HCMV has a large genome, but new methods make it possible for us to understand the role that differences among viral strains play in infection. To make this practical, we have created a rapid way of sequencing complete HCMV genomes directly from clinical samples. We plan to relate viral variation to the outcome of infection in various groups, particularly transplant recipients. This willinvolve analysing viral genome sequences in over 1000 infected patients.In other projects, we will use modern approaches to study the functions of unusual HCMV RNAs and work out whether this might provide new ideas for drugs to treat infections.Finally, we will apply our techniques to a relative of HCMV called human herpesvirus 6 (HHV6). This will help us understand whether the 1% of humans who have an HHV6 genome integrated into all their cells, and are capable of passing it to their children, are at risk of particular diseases.

Andrew Davison博士，首席研究员，与Sheila Graham教授和Ruth Jarrett教授合作，格拉斯哥大学mrc病毒研究中心（CVR），格拉斯哥大学。人类巨细胞病毒（HCMV）对免疫系统不成熟或不能正常工作的人来说是一个严重的问题。它是胎儿感染的主要原因，是移植受者患病的主要原因，也是艾滋病患者的一个问题。HCMV有一个很大的基因组，但新的方法使我们有可能了解病毒株之间的差异在感染中所起的作用。为了实现这一目标，我们已经创建了一种直接从临床样本中对完整HCMV基因组进行测序的快速方法。我们计划将病毒变异与不同群体，特别是移植受者的感染结果联系起来。这将涉及分析1000多名受感染患者的病毒基因组序列。在其他项目中，我们将使用现代方法研究不寻常的HCMV rna的功能，并研究这是否可能为治疗感染的药物提供新思路。最后，我们将把我们的技术应用于HCMV的一种亲戚——人类疱疹病毒6 （HHV6）。这将帮助我们了解1%的人是否有HHV6基因组整合到他们的所有细胞中，并能够将其传递给他们的孩子，他们有患特定疾病的风险。

项目成果

Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017)

• DOI: 10.1007/s00705-017-3358-5
• 发表时间: 2017-08-01
• 期刊: ARCHIVES OF VIROLOGY
• 影响因子: 2.7
• 作者: Adams, Michael J.;Lefkowitz, Elliot J.;Davison, Andrew J.
• 通讯作者: Davison, Andrew J.

Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2016).

• DOI: 10.1007/s00705-016-2977-6
• 发表时间: 2016-10
• 期刊: Archives of virology
• 影响因子: 2.7
• 作者: Adams MJ;Lefkowitz EJ;King AM;Harrach B;Harrison RL;Knowles NJ;Kropinski AM;Krupovic M;Kuhn JH;Mushegian AR;Nibert M;Sabanadzovic S;Sanfaçon H;Siddell SG;Simmonds P;Varsani A;Zerbini FM;Gorbalenya AE;Davison AJ
• 通讯作者: Davison AJ

Eric Carstens: new life member of the International Committee on Taxonomy of Viruses (ICTV).

埃里克·卡斯滕斯（Eric Carstens）：国际病毒分类委员会（ICTV）新任终身委员。

• DOI: 10.1007/s00705-016-3027-0
• 发表时间: 2016
• 期刊: Archives of virology
• 影响因子: 2.7
• 作者: Adams MJ

LoReTTA, a user-friendly tool for assembling viral genomes from PacBio sequence data.

Loretta，一种用户友好的工具，用于从PACBIO序列数据组装病毒基因组。

• DOI: 10.1093/ve/veab042
• 发表时间: 2021-01
• 期刊: Virus evolution
• 影响因子: 5.3
• 作者: Al Qaffas A;Nichols J;Davison AJ;Ourahmane A;Hertel L;McVoy MA;Camiolo S
• 通讯作者: Camiolo S