Innate Immunity and Host Species Barriers
先天免疫和宿主物种障碍
基本信息
- 批准号:MC_UU_12014/10
- 负责人:
- 金额:$ 376.53万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Intramural
- 财政年份:2016
- 资助国家:英国
- 起止时间:2016 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Innate Immunity and Host Species BarrierProf Massimo Palmarini and Dr Sam Wilson, Lead Investigators, with Dr Robert Gifford as a co-investigator and in collaboration with Prof James Neil, MRC-University of Glasgow Centre for Virus Research (CVR), University of GlasgowViral diseases are often in the news because of their ability to suddenly cause an 'outbreak' in human populations. Often this is due to the ability of a virus from animals to 'jump' into humans and start causing disease. Currently, we don't fully understand how viruses 'jump' from one species to another, which hinders our ability to predict which viruses could threaten people in the future.Humans and the animals we share our environment with have all been plagued by viral diseases (some of which are life-threatening) for millions of years. To resist infection, animals have evolved an arsenal of different antiviral defences and every animal has evolved a unique set of these defences. Importantly, these defences can sometimes stop a virus from 'jumping' into a new species.By mapping the antiviral defences in humans and selected domestic and wild animals (like bats and pigs) we will catalogue the diversity of these defences in humans and 'animal reservoirs' of viral diseases. We will use this information to measure the ability of each individual defence to inhibit viruses that threaten human populations. We hope to identify the specific genes that leave us vulnerable to or protect us from the viral diseases circulating in animal populations.
先天免疫和宿主物种屏障Massimo Palmarini教授和Sam Wilson博士,首席研究员,Robert Gifford博士作为共同研究员,并与格拉斯哥大学格拉斯哥病毒研究中心(CVR)的MRC-大学James Neil教授合作。这通常是由于动物病毒能够“跳”到人类身上并开始引起疾病。目前,我们还不完全了解病毒是如何从一个物种“跳”到另一个物种的,这阻碍了我们预测未来哪些病毒可能威胁人类的能力。人类和与我们共享环境的动物都受到病毒疾病的困扰(其中一些是危及生命的)数百万年。为了抵抗感染,动物进化出了一系列不同的抗病毒防御,每种动物都进化出了一套独特的防御。重要的是,这些防御有时可以阻止病毒“跳跃”到一个新的物种。通过绘制人类和选定的家养和野生动物(如蝙蝠和猪)的抗病毒防御,我们将对人类和病毒疾病的“动物宿主”中这些防御的多样性进行编目。我们将利用这些信息来衡量每种防御措施抑制威胁人类的病毒的能力。我们希望能够确定特定的基因,使我们容易受到或保护我们免受在动物种群中传播的病毒性疾病的影响。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Reconstruction of a replication-competent ancestral murine endogenous retrovirus-L.
- DOI:10.1186/s12977-018-0416-3
- 发表时间:2018-05-02
- 期刊:
- 影响因子:3.3
- 作者:Blanco-Melo D;Gifford RJ;Bieniasz PD
- 通讯作者:Bieniasz PD
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses.
- DOI:10.1016/j.cell.2020.10.004
- 发表时间:2020-11-25
- 期刊:
- 影响因子:64.5
- 作者:Banerjee AK;Blanco MR;Bruce EA;Honson DD;Chen LM;Chow A;Bhat P;Ollikainen N;Quinodoz SA;Loney C;Thai J;Miller ZD;Lin AE;Schmidt MM;Stewart DG;Goldfarb D;De Lorenzo G;Rihn SJ;Voorhees RM;Botten JW;Majumdar D;Guttman M
- 通讯作者:Guttman M
The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions.
- DOI:10.1007/s00424-016-1819-4
- 发表时间:2016-06
- 期刊:
- 影响因子:0
- 作者:Beckmann BM;Castello A;Medenbach J
- 通讯作者:Medenbach J
Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation.
- DOI:10.1093/nar/gky873
- 发表时间:2018-12-14
- 期刊:
- 影响因子:14.9
- 作者:Avolio R;Järvelin AI;Mohammed S;Agliarulo I;Condelli V;Zoppoli P;Calice G;Sarnataro D;Bechara E;Tartaglia GG;Landriscina M;Castello A;Esposito F;Matassa DS
- 通讯作者:Matassa DS
RNA-binding protein Mub1 and the nuclear RNA exosome act to fine-tune environmental stress response.
- DOI:10.26508/lsa.202101111
- 发表时间:2022-03
- 期刊:
- 影响因子:4.4
- 作者:Birot A;Kus K;Priest E;Al Alwash A;Castello A;Mohammed S;Vasiljeva L;Kilchert C
- 通讯作者:Kilchert C
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Massimo Palmarini其他文献
Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants
SARS-CoV-2 Omicron 亚变体对增强型先天免疫抑制的进化
- DOI:
10.1038/s41564-023-01588-4 - 发表时间:
2024-01-16 - 期刊:
- 影响因子:19.400
- 作者:
Ann-Kathrin Reuschl;Lucy G. Thorne;Matthew V. X. Whelan;Roberta Ragazzini;Wilhelm Furnon;Vanessa M. Cowton;Giuditta De Lorenzo;Dejan Mesner;Jane L. E. Turner;Giulia Dowgier;Nathasha Bogoda;Paola Bonfanti;Massimo Palmarini;Arvind H. Patel;Clare Jolly;Greg J. Towers - 通讯作者:
Greg J. Towers
Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic
COVID-19 大流行期间 SARS-CoV-2 刺突蛋白的表型进化
- DOI:
10.1038/s41564-024-01878-5 - 发表时间:
2025-01-03 - 期刊:
- 影响因子:19.400
- 作者:
Wilhelm Furnon;Vanessa M. Cowton;Giuditta De Lorenzo;Richard Orton;Vanessa Herder;Diego Cantoni;Georgios Ilia;Diogo Correa Mendonca;Karen Kerr;Jay Allan;Nicole Upfold;Gavin R. Meehan;Siddharth Bakshi;Udeet Ranjan Das;Sergi Molina Arias;Marion McElwee;Sarah Little;Nicola Logan;Kirsty Kwok;Katherine Smollett;Brian J. Willett;Ana Da Silva Filipe;David L. Robertson;Joe Grove;Arvind H. Patel;Massimo Palmarini - 通讯作者:
Massimo Palmarini
Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population
空间解析单细胞图谱揭示了马拉维人群中致命性肺部 COVID-19 的独特细胞特征
- DOI:
10.1038/s41591-024-03354-3 - 发表时间:
2024-11-20 - 期刊:
- 影响因子:50.000
- 作者:
James Nyirenda;Olympia M. Hardy;João Da Silva Filho;Vanessa Herder;Charalampos Attipa;Charles Ndovi;Memory Siwombo;Takondwa Rex Namalima;Leticia Suwedi;Georgios Ilia;Watipenge Nyasulu;Thokozile Ngulube;Deborah Nyirenda;Leonard Mvaya;Joseph Phiri;Dennis Chasweka;Chisomo Eneya;Chikondi Makwinja;Chisomo Phiri;Frank Ziwoya;Abel Tembo;Kingsley Makwangwala;Stanley Khoswe;Peter Banda;Ben Morton;Orla Hilton;Sarah Lawrence;Monique Freire dos Reis;Gisely Cardoso Melo;Marcus Vinicius Guimaraes de Lacerda;Fabio Trindade Maranhão Costa;Wuelton Marcelo Monteiro;Luiz Carlos de Lima Ferreira;Carla Johnson;Dagmara McGuinness;Kondwani Jambo;Michael Haley;Benjamin Kumwenda;Massimo Palmarini;Donna M. Denno;Wieger Voskuijl;Steve Bvuobvuo Kamiza;Kayla G. Barnes;Kevin Couper;Matthias Marti;Thomas D. Otto;Christopher A. Moxon - 通讯作者:
Christopher A. Moxon
NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts
NSm 是布尼亚病毒在脊椎动物和蚊子宿主之间传播的关键决定因素
- DOI:
10.1038/s41467-024-54809-7 - 发表时间:
2025-01-31 - 期刊:
- 影响因子:15.700
- 作者:
Selim Terhzaz;David Kerrigan;Floriane Almire;Agnieszka M. Szemiel;Joseph Hughes;Jean-Philippe Parvy;Massimo Palmarini;Alain Kohl;Xiaohong Shi;Emilie Pondeville - 通讯作者:
Emilie Pondeville
Omics Analyses Uncover Host Networks Defining Virus-Permissive and -Hostile Cellular States
组学分析揭示了决定病毒允许性和敌对性细胞状态的宿主网络
- DOI:
10.1016/j.mcpro.2025.100966 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:5.500
- 作者:
Honglin Chen;Philip D. Charles;Quan Gu;Sabrina Liberatori;David L. Robertson;Massimo Palmarini;Sam J. Wilson;Shabaz Mohammed;Alfredo Castello - 通讯作者:
Alfredo Castello
Massimo Palmarini的其他文献
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{{ truncateString('Massimo Palmarini', 18)}}的其他基金
Virus cross-species transmission. Defining the immunological barriers to viral emergence
病毒跨物种传播。
- 批准号:
MC_UU_00034/3 - 财政年份:2023
- 资助金额:
$ 376.53万 - 项目类别:
Intramural
GeoMx digital spatial profiler: expanding the capabilities of the CVR Virus Genomics and Bioinformatics platform
GeoMx 数字空间分析仪:扩展 CVR 病毒基因组学和生物信息学平台的功能
- 批准号:
MR/X01360X/1 - 财政年份:2022
- 资助金额:
$ 376.53万 - 项目类别:
Research Grant
Monkeypox Rapid Research Response
猴痘快速研究反应
- 批准号:
BB/X011607/1 - 财政年份:2022
- 资助金额:
$ 376.53万 - 项目类别:
Research Grant
MRC Centre for Virus Research (MRC CVR) - COVID-19
MRC 病毒研究中心 (MRC CVR) - COVID-19
- 批准号:
MC_PC_19026 - 财政年份:2020
- 资助金额:
$ 376.53万 - 项目类别:
Intramural
Molecular and reverse genetics studies of orbivirus transmission host responses epidemiology and diagnostic systems
环状病毒传播宿主反应流行病学和诊断系统的分子和反向遗传学研究
- 批准号:
BB/I017224/1 - 财政年份:2011
- 资助金额:
$ 376.53万 - 项目类别:
Research Grant
Improving existing vaccine platforms to minimise the economic impact of emerging Bluetongue virus (BTV) serotypes
改进现有疫苗平台,尽量减少新兴蓝舌病毒 (BTV) 血清型的经济影响
- 批准号:
BB/I003886/1 - 财政年份:2011
- 资助金额:
$ 376.53万 - 项目类别:
Research Grant
MRC-University of Glasgow Centre for Virus Research
MRC-格拉斯哥大学病毒研究中心
- 批准号:
G0801822/1 - 财政年份:2010
- 资助金额:
$ 376.53万 - 项目类别:
Research Grant
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Evasion of plant innate immunity by complex formation between host and viral proteins
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