Dynamics of cell assemblies underlying adaptive and mal-adaptive memories

适应性和适应不良记忆背后的细胞组装动力学

• 批准号: MC_UU_12024/3
• 负责人: David Dupret
• 金额: $ 233.3万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12024%2F3
• 关键词: Dynamics; cell; assemblies; underlying; adaptive

Learning and memory processes rely on the fine coordination of nerve cell activity in several brain regions including the hippocampus and the nucleus accumbens. In this programme we aim to explain how and why nerve activity is organised, not only for understanding normal brain function but also for explaining what goes wrong during memory disorders, including those associating an environment with drugs of abuse. We seek to explain how nerve cells in these brain regions produce accurate patterns of electrical activity that are essential for our memory representations of environments in which salient life events have been experienced. In this work we use cutting edge technologies, ranging from the combined use of rodent behavioural paradigms and brain recordings to light-based manipulation of nerve cell activity. In so doing we place special emphasis on explaining when, why and how special patterns of electrical activity, such as waves or rhythms in different types of nerve cell assist brain operations during normal behaviours. By using light-based tools to experimentally interact with different cell types in these brain circuits we identify patterns of electrical activity that might support abnormal behaviours. In conclusion, this programme of research will allow us to provide novel insights into how nerve cells in the brain coordinate their activity to guide so much of our daily behaviour in both health and disease.

学习和记忆过程依赖于几个大脑区域神经细胞活动的精细协调，包括海马和丘脑核。在这个项目中，我们的目标是解释神经活动是如何以及为什么组织的，不仅是为了理解正常的大脑功能，而且也是为了解释记忆障碍期间出现的问题，包括那些将环境与滥用药物联系起来的问题。我们试图解释这些大脑区域的神经细胞如何产生准确的电活动模式，这些模式对于我们对经历过显着生活事件的环境的记忆表征至关重要。在这项工作中，我们使用尖端技术，从啮齿动物行为模式和大脑记录的结合使用到基于光的神经细胞活动操纵。在这样做的时候，我们特别强调解释什么时候，为什么以及如何特殊模式的电活动，如波或节奏在不同类型的神经细胞在正常行为期间协助大脑运作。通过使用基于光的工具与这些大脑回路中的不同细胞类型进行实验性交互，我们确定了可能支持异常行为的电活动模式。总之，这项研究计划将使我们能够提供新的见解，了解大脑中的神经细胞如何协调它们的活动，以指导我们在健康和疾病中的日常行为。

项目成果

Repetition suppression: a means to index neural representations using BOLD?

• DOI: 10.1098/rstb.2015.0355
• 发表时间: 2016-10-05
• 期刊: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• 作者: Barron HC;Garvert MM;Behrens TE
• 通讯作者: Behrens TE

A checklist for assessing the methodological quality of concurrent tES-fMRI studies (ContES checklist): a consensus study and statement.

• DOI: 10.1038/s41596-021-00664-5
• 发表时间: 2022-03
• 期刊: Nature protocols
• 影响因子: 14.8
• 作者: Ekhtiari H;Ghobadi-Azbari P;Thielscher A;Antal A;Li LM;Shereen AD;Cabral-Calderin Y;Keeser D;Bergmann TO;Jamil A;Violante IR;Almeida J;Meinzer M;Siebner HR;Woods AJ;Stagg CJ;Abend R;Antonenko D;Auer T;Bächinger M;Baeken C;Barron HC;Chase HW;Crinion J;Datta A;Davis MH;Ebrahimi M;Esmaeilpour Z;Falcone B;Fiori V;Ghodratitoostani I;Gilam G;Grabner RH;Greenspan JD;Groen G;Hartwigsen G;Hauser TU;Herrmann CS;Juan CH;Krekelberg B;Lefebvre S;Liew SL;Madsen KH;Mahdavifar-Khayati R;Malmir N;Marangolo P;Martin AK;Meeker TJ;Ardabili HM;Moisa M;Momi D;Mulyana B;Opitz A;Orlov N;Ragert P;Ruff CC;Ruffini G;Ruttorf M;Sangchooli A;Schellhorn K;Schlaug G;Sehm B;Soleimani G;Tavakoli H;Thompson B;Timmann D;Tsuchiyagaito A;Ulrich M;Vosskuhl J;Weinrich CA;Zare-Bidoky M;Zhang X;Zoefel B;Nitsche MA;Bikson M
• 通讯作者: Bikson M

Memory trace replay: the shaping of memory consolidation by neuromodulation.

• DOI: 10.1016/j.tins.2015.07.004
• 发表时间: 2015-09
• 期刊: Trends in neurosciences
• 影响因子: 15.9
• 作者: Atherton LA;Dupret D;Mellor JR
• 通讯作者: Mellor JR