Physiopathology of brain-wide assemblies in adaptive memory

适应性记忆中全脑组装的生理病理学

• 批准号: MC_UU_00003/4
• 负责人: David Dupret
• 金额: $ 289.12万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00003%2F4
• 关键词: Physiopathology; brain; wide; assemblies; adaptive

When making decisions, we often draw on previous experience. This ability to inform behaviour from memory relies on the fine-grained coordination of activity between nerve cells in the brain. The hippocampus is a region of the mammalian brain where the activity of such “cell assemblies” has been related to memory-guided behaviour. However, memories of important life events are expected to span multiple brain regions, with each region processing a particular dimension of information. This organisation of information representation could be at the heart of the complexity of the cognitive disabilities associated with natural ageing and certain neurological/psychiatric diseases. Here, we will first seek to provide a comprehensive mechanistic explanation of how cell activities distributed across multiple brain regions support complex, detail-rich memories. In this work, we will further consider unwanted memories related to drugs of abuse that underpin maladaptive responses, investigating how cross-brain-region communication drives the re-emergence of behaviourally-extinguished drug memory. We will finally identify brain mechanisms of inferential reasoning, a higher-order operation that allows individuals to deduce logical links between sets of information that have not been experienced together. This work is intended to provide principles of interventions to harness brain physiopathology of maladaptive memory.

在做决定时，我们经常借鉴以前的经验。这种从记忆中告知行为的能力依赖于大脑中神经细胞之间活动的细粒度协调。海马体是哺乳动物大脑中的一个区域，在那里这种“细胞集合体”的活动与记忆引导的行为有关。然而，重要生活事件的记忆预计将跨越多个大脑区域，每个区域处理特定维度的信息。这种信息表征的组织可能是与自然衰老和某些神经/精神疾病相关的认知障碍的复杂性的核心。在这里，我们将首先试图提供一个全面的机制解释，说明分布在多个大脑区域的细胞活动如何支持复杂的、细节丰富的记忆。在这项工作中，我们将进一步考虑与滥用药物相关的不必要的记忆，这些记忆是适应不良反应的基础，研究跨脑区通信如何驱动行为消失的药物记忆的重新出现。我们将最终确定推理的大脑机制，这是一种高阶操作，允许个体推断出未一起经历的信息集之间的逻辑联系。这项工作的目的是提供原则的干预措施，以利用大脑病理生理学的适应不良的记忆。

项目成果

An emergent neural coactivity code for dynamic memory.

• DOI: 10.1038/s41593-021-00820-w
• 发表时间: 2021-05
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: El-Gaby M;Reeve HM;Lopes-Dos-Santos V;Campo-Urriza N;Perestenko PV;Morley A;Strickland LAM;Lukács IP;Paulsen O;Dupret D
• 通讯作者: Dupret D

Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

• DOI: 10.1192/bjp.2020.163
• 发表时间: 2021-06
• 期刊: The British journal of psychiatry : the journal of mental science
• 作者: Heinze K;Barron HC;Howes EK;Ramaswami M;Broome MR
• 通讯作者: Broome MR

Over and above frequency: Gamma oscillations as units of neural circuit operations.

• DOI: 10.1016/j.neuron.2023.02.026
• 发表时间: 2023-04-05
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Fernandez-Ruiz A;Sirota A;Lopes-Dos-Santos V;Dupret D
• 通讯作者: Dupret D

A checklist for assessing the methodological quality of concurrent tES-fMRI studies (ContES checklist): a consensus study and statement.

• DOI: 10.1038/s41596-021-00664-5
• 发表时间: 2022-03
• 期刊: Nature protocols
• 影响因子: 14.8
• 作者: Ekhtiari H;Ghobadi-Azbari P;Thielscher A;Antal A;Li LM;Shereen AD;Cabral-Calderin Y;Keeser D;Bergmann TO;Jamil A;Violante IR;Almeida J;Meinzer M;Siebner HR;Woods AJ;Stagg CJ;Abend R;Antonenko D;Auer T;Bächinger M;Baeken C;Barron HC;Chase HW;Crinion J;Datta A;Davis MH;Ebrahimi M;Esmaeilpour Z;Falcone B;Fiori V;Ghodratitoostani I;Gilam G;Grabner RH;Greenspan JD;Groen G;Hartwigsen G;Hauser TU;Herrmann CS;Juan CH;Krekelberg B;Lefebvre S;Liew SL;Madsen KH;Mahdavifar-Khayati R;Malmir N;Marangolo P;Martin AK;Meeker TJ;Ardabili HM;Moisa M;Momi D;Mulyana B;Opitz A;Orlov N;Ragert P;Ruff CC;Ruffini G;Ruttorf M;Sangchooli A;Schellhorn K;Schlaug G;Sehm B;Soleimani G;Tavakoli H;Thompson B;Timmann D;Tsuchiyagaito A;Ulrich M;Vosskuhl J;Weinrich CA;Zare-Bidoky M;Zhang X;Zoefel B;Nitsche MA;Bikson M
• 通讯作者: Bikson M