THE NIDR AMALGAM STUDY

NiDR 汞合金研究

• 批准号: 5201831
• 负责人: A KINGMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201831
• 关键词: biomaterial evaluation; blood chemistry; dental amalgam; dental disorder diagnosis; human subject; mercury; metal dental material; toxicant interaction; toxicology; urinalysis; veterans

This is a major study investigation whether there is any evidence of adverse health effects attributable to exposure to dental amalgams in a specific adult populations. The NIDR Amalgam Study involves 1166 Air Force Veterans, roughly representing a 50% subsample of the Air Force Health Study participants. These participants were examined for scores of medical conditions, including many which would potentially be affected by exposure to mercury. Dental Examinations and blood and urine samples were obtained from the 1166 participants who are in the NIDR Amalgam Study. The exact type of restorative material used in exposure was defined as the total number of surfaces having an amalgam restoration present. All soft tissue conditions detected were obtained. Mercury levels in blood and urine were recorded in ug.1. The amalgam exposure for this cohort was determined to be rather high, averaging 20 surfaces on average. The blood and urinary Hg levels were found to be low, averaging 2.9 ug/1 and 3.1 ug/1, than 15 ug/1, but these levels could not be ascribed to dental amalgam exposure. There was a clear dose response association found between amalgam exposure and urinary Hg levels, but none found between amalgam exposure and blood Hg levels. The health data will be obtained from the AFHS scientists shortly and the tedious, complex analytical process begun.

这是一项重大研究调查是否有任何证据表明 因接触牙科汞合金而对健康产生不利影响 特定的成年人群。 NIDR 汞合金研究涉及 1166 Air 退伍军人，大致代表空军 50% 的子样本 健康研究参与者。 这些参与者接受了分数检查 医疗状况，包括许多可能受到影响的医疗状况 接触汞。 牙科检查以及血液和尿液样本 从 NIDR 汞合金研究的 1166 名参与者中获得。 暴露中使用的修复材料的确切类型被定义为 存在汞合金修复体的表面总数。 都是软的 获得检测到的组织状况。 血液中的汞含量和 尿液记录在ug.1中。 该队列的汞合金暴露量被确定为相当高， 平均 20 个表面。 血液和尿液中的汞含量分别为 发现较低，平均为 2.9 ug/1 和 3.1 ug/1，低于 15 ug/1，但这些 水平不能归因于牙科汞合金暴露。 有一个 汞合金暴露与尿液之间存在明确的剂量反应关联 汞含量，但没有发现汞合金暴露与血液汞含量之间存在差异。 很快就会从 AFHS 科学家那里获得健康数据， 繁琐、复杂的分析过程开始了。