EVALUATIONS OF GENETIC TOXICITY TEST RESULTS

遗传毒性试验结果评价

• 批准号: 5202105
• 负责人: E ZEIGER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5202105
• 关键词: DNA damage; carcinogen testing; chemical carcinogen; chemical carcinogenesis; chemical information system; chemical structure function; chromosome aberrations; laboratory mouse; mutagen testing; mutagens; toxicant screening; toxicology information system

A database of NTP short-term genetic toxicity test results and the results from carcinogenesis tests has been created. This database allows the evaluation of each short-term assay with respect to its ability to predict carcinogenesis or other short-term assay results. It also permits studies of the individual assays with respect to inter- and intra-laboratory reproducibiliity. Examination of test predictivity as a function of the potency of the short-term test (STT) and carcinogenicity test is continuing. The chemicals being evaluated comprise the 114-chemical database used previously to correlate qualitative STT results with carcinogenicity results. The short-term genetic toxicity results are being integrated with other toxicity and biochemical parameters of these chemicals in an attempt to improve the prediction of carcinogenicity and other toxic effects. The relationships among different mutagenic potency measures for the Salmonella test, in vitro chromosome aberrations and SCEs, and the mouse lymphoma mutagenicity test have been evaluated, and their predictivities for (qualitative and quantitative) carcinogenicity have been determined. A manuscript describing these evaluations for the Salmonella test has been submitted for publication. Manuscripts describing the relationships between gemotoxic potency and carcinogenicity for the other genetic toxicity tests are in preparation.

NTP短期遗传毒性试验结果数据库和 致癌性测试的结果已经产生。 该数据库允许 评价每个短期试验的能力， 预测致癌作用或其他短期测定结果。 它还 允许研究个体测定， 实验室内重现性。 检验预测性， 短期试验（STT）效价的函数，以及 致癌性测试仍在进行中。正在评估的化学品 包括以前用于关联的114种化学物质数据库， 定性STT结果和致癌性结果。 短期 遗传毒性结果正在与其他毒性结果相结合， 这些化学品的生化参数，试图改善 预测致癌性和其他毒性作用。 不同致突变效力指标之间的关系 沙门氏菌试验、体外染色体畸变和SCE以及小鼠 淋巴瘤致突变性试验进行了评价， （定性和定量）致癌性。 一份描述沙门氏菌测试这些评估的手稿， 已提交出版。 描述关系的手册 基因毒性和致癌性之间的关系 毒性测试正在准备中。