ROLE OF INTERLEUKIN 10 IN ENDOTOXIN INDUCED UVEITIS

本课题研究白介素10(IL-10)在葡萄膜炎中的作用。 皮下注射细菌诱导小鼠葡萄膜炎 内毒素。眼内炎症通过白细胞计数进行评估 以及房水中蛋白质浓度的测量。小白鼠 重组IL-10或其载体单独通过重复给药 静脉注射。 在五个实验中的四个中，眼睛中的细胞渗透是 显著减少。细胞数量减少了62%， 分别为48%、11%和40% IL-10治疗组与对照组比较。IL-10 不影响蛋白质渗出。 我们得出结论，全身应用IL-10具有抗 炎症对免疫细胞成分的影响 内毒素介导的葡萄膜炎的反应。

This project studies the role of interleukin-10 (IL-10) in uveitis. Uveitis was induced in mice by subcutaneous injection of bacterial endotoxin. Intraocular inflammation was assessed by leukocyte count and protein concentration measurement in the aqueous humor. Mouse recombinant IL-10 or its vehicle alone were administered by repeated intravenous injections. In four of five experiments, the cellular infiltration in the eye was significantly reduced. The number of cells was reduced by 62 percent, 64 percent, 48 percent, 11 percent, and 40 percent, respectively, in the group treated with IL-10 compared with the control group. IL-10 did not affect protein exudation. We conclude that systemic administration of IL-10 has an anti- inflammatory effect acting on the cellular component of the immune response in endotoxin-mediated uveitis.