STUDY OF OCULAR GLIAL CELLS INVOLVEMENT IN UVEITIS

这项工作扩展了我们正在进行的视网膜之间相互作用的研究 胶质穆勒细胞和T淋巴细胞。在体外共培养系统中， 穆勒细胞已被证明对 T辅助细胞系通过膜结合因子的增殖。 对抑制部分的性质的研究表明，它是 对蛋白酶敏感。进一步的研究表明，该基因的表达 MULER细胞表面因子可被抑制 糖皮质激素。

This work extended our ongoing study of interactions between the retinal glial Muller cell and T-lymphocytes. In an in vitro coculture system, Muller cells had been shown to exert a profound inhibitory influence on the proliferation of T-helper cell lines through a membrane-bound factor. Investigations of the nature of the inhibitory moiety revealed that it was sensitive to proteinase. Further studies showed that the expression of the factor on the surface of Muller cells could be suppressed by glucocorticoids.